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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 13, Iss. 21 — Oct. 17, 2005
  • pp: 8532–8546

Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging

Robert J. Zawadzki, Steven M. Jones, Scot S. Olivier, Mingtao Zhao, Bradley A. Bower, Joseph A. Izatt, Stacey Choi, Sophie Laut, and John S. Werner  »View Author Affiliations

Optics Express, Vol. 13, Issue 21, pp. 8532-8546 (2005)

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We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (~4 μm) of retinal images, while maintaining the high axial resolution (~6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

© 2005 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.1000) Optical design and fabrication : Aberration compensation

ToC Category:
Research Papers

Original Manuscript: August 15, 2005
Revised Manuscript: October 4, 2005
Published: October 17, 2005

Robert Zawadzki, Steven Jones, Scot Olivier, Mingtao Zhao, Bradley Bower, Joseph Izatt, Stacey Choi, Sophie Laut, and John Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005)

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