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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 13 — Jun. 25, 2007
  • pp: 8043–8058

Structural information within regularization matrices improves near infrared diffuse optical tomography

Phaneendra K. Yalavarthy, Brian W. Pogue, Hamid Dehghani, Colin M. Carpenter, Shudong Jiang, and Keith D. Paulsen  »View Author Affiliations

Optics Express, Vol. 15, Issue 13, pp. 8043-8058 (2007)

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Near-Infrared (NIR) tomographic image reconstruction is a non-linear, ill-posed and ill-conditioned problem, and so in this study, different ways of penalizing the objective function with structural information were investigated. A simple framework to incorporate structural priors is presented, using simple weight matrices that have either Laplacian or Helmholtz-type structures. Using both MRI-derived breast geometry and phantom data, a systematic and quantitative comparison was performed with and without spatial priors. The Helmholtz-type structure can be seen as a more generalized approach for incorporating spatial priors into the reconstruction scheme. Moreover, parameter reduction (i.e. hard prior information) in the imaging field through the enforcement of spatially explicit regions may lead to erroneous results with imperfect spatial priors.

© 2007 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: March 26, 2007
Revised Manuscript: June 11, 2007
Manuscript Accepted: June 11, 2007
Published: June 13, 2007

Virtual Issues
Vol. 2, Iss. 7 Virtual Journal for Biomedical Optics

Phaneendra K. Yalavarthy, Brian W. Pogue, Hamid Dehghani, Colin M. Carpenter, Shudong Jiang, and Keith D. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Opt. Express 15, 8043-8058 (2007)

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