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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 20 — Oct. 1, 2007
  • pp: 12636–12653

Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography

Jeff Fingler, Dan Schwartz, Changhuei Yang, and Scott E. Fraser  »View Author Affiliations


Optics Express, Vol. 15, Issue 20, pp. 12636-12653 (2007)
http://dx.doi.org/10.1364/OE.15.012636


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Abstract

Phase variance-based motion contrast is demonstrated using two phase analysis methods in a spectral domain optical coherence tomography system. Mobility contrast is demonstrated for an intensity matched Intralipid solution placed without flow within agarose wells. Vasculature oriented transversely to the imaging direction has been imaged for 3-4 dpf in vivo zebrafish using the phase variance contrast methods. 2D phase variance contrast images are demonstrated with imaging times only 25% higher than a Doppler flow image with comparable statistics. En face images created by integrating depth regions of 3D zebrafish intensity and phase variance contrast data demonstrate vasculature consistent with expected images.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Imaging Systems

History
Original Manuscript: May 11, 2007
Revised Manuscript: September 11, 2007
Manuscript Accepted: September 13, 2007
Published: September 18, 2007

Virtual Issues
Vol. 2, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Jeff Fingler, Dan Schwartz, Changhuei Yang, and Scott E. Fraser, "Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography," Opt. Express 15, 12636-12653 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-20-12636


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