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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 21 — Oct. 17, 2007
  • pp: 13574–13584

Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography

Johan Axelsson, Jenny Svensson, and Stefan Andersson-Engels  »View Author Affiliations

Optics Express, Vol. 15, Issue 21, pp. 13574-13584 (2007)

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Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.

© 2007 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(260.2510) Physical optics : Fluorescence

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 8, 2007
Revised Manuscript: September 25, 2007
Manuscript Accepted: September 26, 2007
Published: October 1, 2007

Virtual Issues
Vol. 2, Iss. 11 Virtual Journal for Biomedical Optics

Johan Axelsson, Jenny Svensson, and Stefan Andersson-Engels, "Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography," Opt. Express 15, 13574-13584 (2007)

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