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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 21 — Oct. 17, 2007
  • pp: 13715–13730

Quantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy

Ye Yang, Olusola Soyemi, Peter J. Scott, Michelle R. Landry, Stuart M. Lee, Leah Stroud, and Babs R. Soller  »View Author Affiliations

Optics Express, Vol. 15, Issue 21, pp. 13715-13730 (2007)

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A method to non-invasively and quantitatively measure muscle oxygen saturation (SmO2) using broadband continuous-wave diffuse reflectance near infrared (NIR) spectroscopy is presented. The method obtained SmO2 by first correcting NIR spectra for absorption and scattering of skin pigment and fat, then fitting to a Taylor expansion attenuation model. A non-linear least squares optimization algorithm with set boundary constraints on the fitting parameters was used to fit the model to the acquired spectra. A data preprocessing/optimization scheme for accurately determining the initial values needed for the optimization was also employed. The method was evaluated on simulated muscle spectra with 4 different scattering properties, as well as on in vivo forearm spectra from 5 healthy volunteer subjects during arterial occlusion. Measurement repeatability was assessed on 24 healthy volunteers with 5 repeated measurements, each separated by at least 48 hours.

© 2007 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: August 8, 2007
Revised Manuscript: September 25, 2007
Manuscript Accepted: October 1, 2007
Published: October 4, 2007

Virtual Issues
Vol. 2, Iss. 11 Virtual Journal for Biomedical Optics

Ye Yang, Olusola Soyemi, Peter J. Scott, Michelle R. Landry, Stuart M. Lee, Leah Stroud, and Babs R. Soller, "Quantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy," Opt. Express 15, 13715-13730 (2007)

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