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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 25 — Dec. 10, 2007
  • pp: 17410–17423

High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria

Hai-Cang Ren, Frank Vollmer, Stephen Arnold, and Albert Libchaber  »View Author Affiliations


Optics Express, Vol. 15, Issue 25, pp. 17410-17423 (2007)
http://dx.doi.org/10.1364/OE.15.017410


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Abstract

Theory is developed for frequency shift and linewidth-broadening induced by rodlike bacteria bound to micro-optical resonators. Optical shift of whispering gallery modes (WGMs) is modeled by introducing a form factor that accounts for random horizontal orientation of cylindrical bacteria bound by their high refractive index cell walls. Linewidth-broadening is estimated from scattering losses. Analytic results are confirmed by measurement using E.Coli as model system (~102 bacteria/mm2 sensitivity), establishing the WGM biosensor as sensitive technique for detection and analysis of micro-organisms.

© 2007 Optical Society of America

OCIS Codes
(170.1420) Medical optics and biotechnology : Biology
(170.1530) Medical optics and biotechnology : Cell analysis
(230.5750) Optical devices : Resonators
(240.0310) Optics at surfaces : Thin films

ToC Category:
Sensors

History
Original Manuscript: July 27, 2007
Revised Manuscript: August 29, 2007
Manuscript Accepted: September 19, 2007
Published: December 10, 2007

Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics
Physics and Applications of Microresonators (2007) Optics Express

Citation
Hai-Cang Ren, Frank Vollmer, Stephen Arnold, and Albert Libchaber, "High-Q microsphere biosensor - analysis for adsorption of rodlike bacteria," Opt. Express 15, 17410-17423 (2007)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-25-17410


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