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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 11 — May. 26, 2008
  • pp: 8126–8143

Optics InfoBase > Optics Express > Volume 16 > Issue 11 > Page 8126

Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction

Robert J. Zawadzki, Barry Cense, Yan Zhang, Stacey S. Choi, Donald T. Miller, and John S. Werner  »View Author Affiliations


Optics Express, Vol. 16, Issue 11, pp. 8126-8143 (2008)
http://dx.doi.org/10.1364/OE.16.008126


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Abstract

We have developed an improved adaptive optics - optical coherence tomography (AO-OCT) system and evaluated its performance for in vivo imaging of normal and pathologic retina. The instrument provides unprecedented image quality at the retina with isotropic 3D resolution of 3.5×3.5×3.5 µm3. Critical to the instrument’s resolution is a customized achromatizing lens that corrects for the eye’s longitudinal chromatic aberration and an ultra broadband light source (Δλ=112nm λ0=~836 nm). The eye’s transverse chromatic aberrations is modeled and predicted to be sufficiently small for the imaging conditions considered. The achromatizing lens was strategically placed at the light input of the AO-OCT sample arm. This location simplifies use of the achromatizing lens and allows straightforward implementation into existing OCT systems. Lateral resolution was achieved with an AO system that cascades two wavefront correctors, a large stroke bimorph deformable mirror (DM) and a micro-electromechanical system (MEMS) DM with a high number of actuators. This combination yielded diffraction-limited imaging in the eyes examined. An added benefit of the broadband light source is the reduction of speckle size in the axial dimension. Additionally, speckle contrast was reduced by averaging multiple B-scans of the same proximal patch of retina. The combination of improved micron-scale 3D resolution, and reduced speckle size and contrast were found to significantly improve visibility of microscopic structures in the retina.

© 2008 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(110.4500) Imaging systems : Optical coherence tomography
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.0110) Medical optics and biotechnology : Imaging systems
(170.4470) Medical optics and biotechnology : Ophthalmology
(220.1000) Optical design and fabrication : Aberration compensation

ToC Category:
Imaging Systems

History
Original Manuscript: March 24, 2008
Revised Manuscript: May 16, 2008
Manuscript Accepted: May 17, 2008
Published: May 20, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Robert J. Zawadzki, Barry Cense, Yan Zhang, Stacey S. Choi, Donald T. Miller, and John S. Werner, "Ultrahigh-resolution optical coherence tomography with monochromatic and chromatic aberration correction," Opt. Express 16, 8126-8143 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-11-8126


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References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Flotte, K. Gregory, and C. A. Puliafito, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and Y. Elzaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
  3. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
  4. N. A. Nassif, B. Cense, B. H. Park, M. C. Pierce, S. H. Yun, B. E. Bouma, G. J. Tearney, T. C. Chen, and J. F. de Boer, "In vivo high-resolution video-rate spectral-domain optical coherence tomography of the human retina and optic nerve," Opt. Express 12, 367-376 (2004). [CrossRef] [PubMed]
  5. M. Wojtkowski, V. Srinivasan, J. Fujimoto, T. Ko, J. Schuman, A. Kowalczyk, and J. Duker, "Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography," Ophthalmology,  112, 1734-1746 (2005). [CrossRef] [PubMed]
  6. S. Alam, R. J. Zawadzki, S. S. Choi, C. Gerth, S. S. Park, L. Morse, and J. S. Werner, "Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging," Ophthalmology 113, 1425-1431 (2006). [CrossRef] [PubMed]
  7. S. N. Truong, S. Alam, R. J. Zawadzki, S. S. Choi, D. G. Telander, S. S. Park, J. S. Werner and L. S. Morse, "High-resolution Fourier-domain optical coherence tomography of retinal angiomatous proliferation," Retina 27, 915-925 (2007). [CrossRef] [PubMed]
  8. W. Drexler and J. G. Fujimoto, "Optical coherence tomography in ophthalmology" J. Biomed. Opt. 12, 041201 (2007). [CrossRef]
  9. W. J. Donnelly III and A. Roorda, "Optimal pupil size in the human eye for axial resolution," J. Opt. Soc. Am. A 20, 2010-2015 (2003), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-20-11-2010. [CrossRef]
  10. J. Liang, D. R. Williams and D. T. Miller, "Supernormal vision and high-resolution retinal imaging through adaptive optics," J. Opt. Soc. Am. A 14, 2884 (1997), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-14-11-2884. [CrossRef]
  11. A. Roorda, F. Romero-Borja, W. J. Donnelly III, H. Queener, T. J. Hebert, and M. C. W. Campbell, "Adaptive optics scanning laser ophthalmoscopy," Opt. Express 10, 405-412 (2002). [PubMed]
  12. D. T. Miller, J. Qu, R. S. Jonnal, and K. Thorn, "Coherence gating and adaptive optics in the eye," Proc. SPIE 4956, 65-72 (2003). [CrossRef]
  13. B. Hermann, E. J. Fernandez, A. Unterhubner, H. Sattmann, A. F. Fercher, and W. Drexler, P. M. Prieto and P. Artal, "Adaptive-optics ultrahigh-resolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004). [CrossRef] [PubMed]
  14. D. Merino, C. Dainty, A. Bradu, and A. G. Podoleanu, "Adaptive optics enhanced simultaneous en-face optical coherence tomography and scanning laser ophthalmoscopy," Opt. Express 14, 3345-3353 (2006). [CrossRef] [PubMed]
  15. Y. Zhang, J. Rha, R. S. Jonnal, D. T. Miller, "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005). [CrossRef] [PubMed]
  16. R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005). [CrossRef] [PubMed]
  17. Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006). [CrossRef] [PubMed]
  18. E. Fernández, B. Povazay, B. Hermann, A. Unterhuber, H. Sattman, P. Prieto, R. Leitgeb, P. Anhelt, P. Artal, W. Drexler, "Three-dimensional adaptive optics ultrahigh-resolution optical coherence tomography using liquid crystal spatial light modulator," Vision. Res. 45, 3432-3444 (2005). [CrossRef] [PubMed]
  19. R. J. Zawadzki, S. S. Choi, S. M. Jones, S. S. Olivier, J. S. Werner, "Adaptive optics - optical coherence tomography: optimizing visualization of microscopic retinal structures in three dimensions." J. Opt. Soc. Am. A 24, 1373-1383 (2007). [CrossRef]
  20. C. E. Bigelow, N. V. Iftimia, R. D. Ferguson, T. E. Ustun, B. Bloom, and D. X. Hammer, "Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging," J. Opt. Soc. Am. A 24, 1327-1336 (2007), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-24-5-1327. [CrossRef]
  21. M. Pircher, R. J. Zawadzki, J. W. Evans, J. S. Werner and C. K. Hitzenberger, "Simultaneous imaging of human cone mosaic with adaptive optics enhanced scanning laser ophthalmoscopy and high- speed transversal scanning optical coherence tomography," Opt. Lett. 33, 22-24 (2008), http://www.opticsinfobase.org/abstract.cfm?URI=oe-10-9-405. [CrossRef]
  22. M. Pircher and R. J. Zawadzki, "Combining adaptive optics with optical coherence tomography: Unveiling the cellular structure of the human retina in vivo," Expert Review of Ophthalmology 2, 1019-1035 (2007). [CrossRef]
  23. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kartner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001). [CrossRef] [PubMed]
  24. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003), http://www.opticsinfobase.org/abstract.cfm?URI=ol-28-21-2067. [CrossRef] [PubMed]
  25. R. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003). [CrossRef] [PubMed]
  26. B. Cense, N. A. Nassif, T. C. Chen, M. C. Pierce, S. H. Yun, B. H. Park, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "Ultrahigh-resolution high-speed retinal imaging using spectral-domain optical coherence tomography," Opt. Express 12, 2435-2447 (2004). [CrossRef] [PubMed]
  27. M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J.G. Fujimoto, A. Kowalczyk, and J. S. Duker, "Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation," Opt. Express 12, 2404-2422 (2004). [CrossRef] [PubMed]
  28. T. M. Jørgensen, J. Thomadsen, U. Christensen, W. Soliman, and B. Sander, "Enhancing the signal-to-noise ratio in ophthalmic optical coherence tomography by image registration�??method and clinical examples" J. Biomed. Opt. 12, 041208 (2007). [CrossRef] [PubMed]
  29. D. A. Atchison and G. Smith, Optics of the Human Eye (Butterworth-Heinemann, 2000).
  30. E. J. Fernández, A. Unterhuber, P. M. Prieto, B. Hermann, W. Drexler, and P. Artal, "Ocular aberrations as a function of wavelength in the near infrared measured with a femtosecond laser," Opt. Express 13, 400-409 (2005). [CrossRef] [PubMed]
  31. E. J. Fernández, A. Unterhuber, B. Považay, B. Hermann, P. Artal, and W. Drexler, "Chromatic aberration correction of the human eye for retinal imaging in the near infrared," Opt. Express 14, 6213-6225 (2006). [CrossRef] [PubMed]
  32. D. A. Atchison and G. Smith, "Chromatic dispersions of the ocular media of human eyes," J. Opt. Soc. Am. A 22, 29-37 (2005), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-22-1-29. [CrossRef]
  33. A. C. van Heel, "Correcting the spherical and chromatic aberrations of the eye," J. Opt. Soc. Am. 36, 237-239 (1947).
  34. R. E. Bedford and G. Wyszecki, "Axial chromatic aberration of the human eye," J. Opt. Soc. Am. 47, 564-565 (1957). [CrossRef] [PubMed]
  35. A. L. Lewis, M. Katz, and C. Oehrlein, "A modified achromatizing lens," Am. J. Optom. Physiol. Opt. 59, 909-911 (1982). [PubMed]
  36. R. Navarro, J. Santamaria, and J. Bescos, "Accommodation-dependent model of the human eye with aspherics," J. Opt. Soc. Am. A 2, 1273 - 1281 (1985), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-2-8-1273. [CrossRef] [PubMed]
  37. I. Powell, "Lenses for correcting chromatic aberration of the eye," Appl. Opt. 20, 4152-4155 (1981). [CrossRef] [PubMed]
  38. Y. Benny, S. Manzanera, P. M. Prieto, E. N. Ribak, and P. Artal, "Wide-angle chromatic aberration corrector for the human eye," J. Opt. Soc. Am. A 24, 1538-1544 (2007). [CrossRef]
  39. X. Zhang, A. Bradley, and L. N. Thibos, "Achromatizing the human eye: the problem of chromatic parallax," J. Opt. Soc. Am. A 8, 686-691 (1991), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-8-4-686. [CrossRef] [PubMed]
  40. L. N. Thibos, "Calculation of the influence of lateral chromatic aberration on image quality across the visual field," J. Opt. Soc. Am. A 4, 1673-1680 (1987), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-4-8-1673. [CrossRef] [PubMed]
  41. X. Zhang, A. Bradley, and L. N. Thibos, "Experimental determination of the chromatic difference of magnification of the human eye and the location of the anterior nodal point," J. Opt. Soc. Am. A 10, 213-220 (1993), http://www.opticsinfobase.org/abstract.cfm?URI=josaa-10-2-213. [CrossRef] [PubMed]
  42. M. Rynders, B. Lidkea, W. Chisholm, and L. N. Thibos, "Statistical distribution of foveal transverse chromatic aberration, pupil centration, and angle �? in a population of young adult eyes," J. Opt. Soc. Am. A 12, 2348-2357 (1995). [CrossRef]

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