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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 16, Iss. 3 — Feb. 4, 2008
  • pp: 1577–1582

Microfluidic devices for terahertz spectroscopy of biomolecules

Paul A. George, Wallace Hui, Farhan Rana, Benjamin G. Hawkins, A. Ezekiel Smith, and Brian J. Kirby  »View Author Affiliations


Optics Express, Vol. 16, Issue 3, pp. 1577-1582 (2008)
http://dx.doi.org/10.1364/OE.16.001577


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Abstract

We demonstrate microfluidic devices for terahertz spectroscopy of biomolecules in aqueous solutions. The devices are fabricated out of a plastic material that is both mechanically rigid and optically transparent with near-zero dispersion in the terahertz frequency range. Using a low-power terahertz time-domain spectrometer, we experimentally measure the absorption spectra of the vibrational modes of bovine serum albumin from 0.5–2.5 THz and find good agreement with previously reported data obtained using large-volume solutions and a high-power free-electron laser. Our results demonstrate the feasibility of performing high sensitivity terahertz spectroscopy of biomolecules in aqueous solutions with detectable molecular quantities as small as 10 picomoles using microfluidic devices.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(230.0230) Optical devices : Optical devices
(280.0280) Remote sensing and sensors : Remote sensing and sensors
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Spectroscopy

History
Original Manuscript: December 3, 2007
Revised Manuscript: January 10, 2008
Manuscript Accepted: January 11, 2008
Published: January 23, 2008

Virtual Issues
Vol. 3, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Paul A. George, Wallace Hui, Farhan Rana, Benjamin G. Hawkins, A. Ezekiel Smith, and Brian J. Kirby, "Microfluidic devices for terahertz spectroscopy of biomolecules," Opt. Express 16, 1577-1582 (2008)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-16-3-1577


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