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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 10 — May. 11, 2009
  • pp: 8062–8080

Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information

Yujie Lu, Xiaoqun Zhang, Ali Douraghy, David Stout, Jie Tian, Tony F. Chan, and Arion F. Chatziioannou  »View Author Affiliations


Optics Express, Vol. 17, Issue 10, pp. 8062-8080 (2009)
http://dx.doi.org/10.1364/OE.17.008062


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Abstract

Through restoration of the light source information in small animals in vivo, optical molecular imaging, such as fluorescence molecular tomography (FMT) and bioluminescence tomography (BLT), can depict biological and physiological changes observed using molecular probes. A priori information plays an indispensable role in tomographic reconstruction. As a type of a priori information, the sparsity characteristic of the light source has not been sufficiently considered to date. In this paper, we introduce a compressed sensing method to develop a new tomographic algorithm for spectrally-resolved bioluminescence tomography. This method uses the nature of the source sparsity to improve the reconstruction quality with a regularization implementation. Based on verification of the inverse crime, the proposed algorithm is validated with Monte Carlo-based synthetic data and the popular Tikhonov regulariz ion method. Testing with different noise levels and single/multiple source settings at different depths demonstrates the improved performance of this algorithm. Experimental reconstruction with a mouse-shaped phantom further shows the potential of the proposed algorithm.

© 2009 Optical Society of America

OCIS Codes
(110.6960) Imaging systems : Tomography
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6280) Medical optics and biotechnology : Spectroscopy, fluorescence and luminescence

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: March 26, 2009
Revised Manuscript: April 25, 2009
Manuscript Accepted: April 26, 2009
Published: April 29, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Yujie Lu, Xiaoqun Zhang, Ali Douraghy, David Stout, Jie Tian, Tony F. Chan, and Arion F. Chatziioannou, "Source Reconstruction for Spectrally-resolved Bioluminescence Tomography with Sparse A priori Information," Opt. Express 17, 8062-8080 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-10-8062


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