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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 13 — Jun. 22, 2009
  • pp: 10489–10498

A real-time photoacoustic tomography system for small animals

John Gamelin, Anastasios Maurudis, Andres Aguirre, Fei Huang, Puyun Guo, Lihong V. Wang, and Quing Zhu  »View Author Affiliations


Optics Express, Vol. 17, Issue 13, pp. 10489-10498 (2009)
http://dx.doi.org/10.1364/OE.17.010489


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Abstract

A real-time 512-element photoacoustic tomography system for small animal imaging using a ring ultrasound array has been developed. The system, based upon a 5 MHz transducer array formed along a 50 mm circular aperture, achieves sub-200 micron lateral resolution over a 2 cm disk-shaped region. Corresponding elevation resolutions of 0.6 to 2.5 mm over the central volume enable depth-resolved 3D tomographic imaging with linear translation. Using 8:1 electronic multiplexing, imaging at up to 8 frame/sec is demonstrated for both dynamic phantoms and in vivo mouse and brain samples. The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame.

© 2009 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(110.5120) Imaging systems : Photoacoustic imaging
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 3, 2009
Revised Manuscript: May 17, 2009
Manuscript Accepted: May 18, 2009
Published: June 8, 2009

Virtual Issues
Vol. 4, Iss. 8 Virtual Journal for Biomedical Optics

Citation
John Gamelin, Anastasios Maurudis, Andres Aguirre, Fei Huang, Puyun Guo, Lihong V. Wang, and Quing Zhu, "A real-time photoacoustic tomography system for small animals," Opt. Express 17, 10489-10498 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-13-10489


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References

  1. J. T. Oh, M. L. Li, H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy,” J. Biomed. Opt. 11(3), 34032 (2006). [CrossRef] [PubMed]
  2. R. J. Zemp, R. Bitton, M. L. Li, K. K. Shung, G. Stoica, and L. V. Wang, “Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer,” J. Biomed. Opt. 12(1), 010501 (2007). [CrossRef] [PubMed]
  3. X. Wang, D. L. Chamberland, and D. A. Jamadar, “Noninvasive photoacoustic tomography of human peripheral joints toward diagnosis of inflammatory arthritis,” Opt. Lett. 32(20), 3002–3004 (2007). [CrossRef] [PubMed]
  4. G. F. Lungu, M. L. Li, X. Xie, L. V. Wang, and G. Stoica, “In vivo imaging and characterization of hypoxia-induced neovascularization and tumor invasion,” Int. J. Oncol. 30(1), 45–54 (2007).
  5. E. Zhang, J. Laufer, and P. Beard, “Three-dimensional photoacoustic imaging of vascular anatomy in small animals using an optical detection system,” Proc. SPIE 6437, 64370S (2007). [CrossRef]
  6. S. Manohar, A. Kharine, J. C. van Hespen, W. Steenbergen, and T. G. van Leeuwen, “The Twente Photoacoustic Mammoscope: system overview and performance,” Phys. Med. Biol. 50(11), 2543–2557 (2005). [CrossRef] [PubMed]
  7. S. A. Ermilov, R. Gharieb, A. Conjusteau, and A. A. Oraevsky, “Hybrid optoacoustic and ultrasonic imaging system for detection of prostate malignancies,” Proc. SPIE 6856, 68560T (2008).
  8. R. G. Kolkman, P. J. Brands, W. Steenbergen, and T. G. van Leeuwen, “Real-time in vivo photoacoustic and ultrasound imaging,” J. Biomed. Opt. 13(5), 050510 (2008). [CrossRef] [PubMed]
  9. J. J. Niederhauser, M. Jaeger, R. Lemor, P. Weber, and M. Frenz, “Combined ultrasound and optoacoustic system for real-time high-contrast vascular imaging in vivo,” IEEE Trans. Med. Imaging 24(4), 436–440 (2005). [CrossRef] [PubMed]
  10. S. Park, S. Mallidi, A. Karpiouk, S. Alyamov, and S. Emelianov, “Photoacoustic imaging using array transducer,” Proc. SPIE 6437, 643714 (2007). [CrossRef]
  11. B. Yin, D. Xing, Y. Wang, Y. Zeng, Y. Tan, and Q. Chen, “Fast photoacoustic imaging system based on 320-element linear transducer array,” Phys. Med. Biol. 49(7), 1339–1346 (2004). [CrossRef] [PubMed]
  12. Y. Lao, D. Xing, S. Yang, and L. Xiang, “Noninvasive photoacoustic imaging of the developing vasculature during early tumor growth,” Phys. Med. Biol. 53(15), 4203–4212 (2008). [CrossRef] [PubMed]
  13. S. Yang, D. Xing, Q. Zhou, L. Xiang, and Y. Lao, “Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography,” Med. Phys. 34(8), 3294–3301 (2007). [CrossRef] [PubMed]
  14. E. Z. Zhang, J. G. Laufer, R. B. Pedley, and P. C. Beard, “In vivo high-resolution 3D photoacoustic imaging of superficial vascular anatomy,” Phys. Med. Biol. 54(4), 1035–1046 (2009). [CrossRef] [PubMed]
  15. J. Gamelin, A. Aguirre, A. Maurudis, F. Huang, D. Castillo, L. V. Wang, and Q. Zhu, “Curved array photoacoustic tomographic system for small animal imaging,” J. Biomed. Opt. 13(2), 024007 (2008). [CrossRef] [PubMed]
  16. J. Gamelin, A. Maurudis, A. Aguirre, F. Huang, P. Guo, L. H. V. Wang, and Q. Zhu, “A fast 512-element ring array photoacoustic imaging system for small animals,” Proc. SPIE 7177, 70 (2009).
  17. J. A. Jensen, “Field: A Program for Simulating Ultrasound Systems,” Med. Biol. Eng. Comput. 34, 351–353 (1996).
  18. J. Gamelin, A. Aguire, A. Maurudis, F. Huang, D. Castillo, L. H. V. Wang, and Q. Zhu, Photoacoustic Imaging and Spectroscopy (Taylor and Francis, 2008), Chap. 25.
  19. M. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 71(1 Pt 2), 016706 (2005). [CrossRef] [PubMed]
  20. M. Xu and L. V. Wang, “Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 67(5 Pt 2), 056605 (2003). [CrossRef] [PubMed]
  21. J. Gamelin, A. Maurudis, A. Aguirre, L. H. V. Wang, and Q. Zhu, “Improvements in time resolution of Tomographic Photoacoustic Imaging using a priori Information for Multiplexed Systems,” Proc. SPIE 7177, 49 (2009).
  22. X. Wang, Y. Pang, G. Ku, X. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol. 21(7), 803–806 (2003). [CrossRef] [PubMed]
  23. X. Wang, G. Ku, M. A. Wegiel, D. J. Bornhop, G. Stoica, and L. V. Wang, “Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent,” Opt. Lett. 29(7), 730–732 (2004). [CrossRef] [PubMed]
  24. X. Yang, L. V. Wang, A. Maurudis, J. Gamelin, and A. Aguirre, “Three-dimensional photoacoustic tomography of small animal brain with a curved array transducer,” Proc. SPIE 7177, 118–122 (2009).

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