Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy
Optics Express, Vol. 17, Issue 15, pp. 12532-12539 (2009)
http://dx.doi.org/10.1364/OE.17.012532
Enhanced HTML
Acrobat PDF (364 KB)
Abstract
We present a novel intracavity frequency modulation scheme in a tunable, picosecond optical parametric oscillator (OPO). The OPO signal wavelength can be modulated with a depth of more than 10 nm at a rate of 38 MHz (one half its repetition rate). We discuss the design and construction of the light source and its application to the recently-developed frequency modulation coherent anti-Stokes Raman scattering (FM-CARS) and stimulated Raman scattering (SRS) techniques. The new light source allows for real time subtraction of the interfering background signal in coherent Raman imaging, yielding images with purely chemical contrast.
© 2009 OSA
OCIS Codes
(190.4360) Nonlinear optics : Nonlinear optics, devices
(140.3518) Lasers and laser optics : Lasers, frequency modulated
(180.4315) Microscopy : Nonlinear microscopy
ToC Category:
Nonlinear Optics
History
Original Manuscript: May 28, 2009
Revised Manuscript: June 29, 2009
Manuscript Accepted: July 2, 2009
Published: July 20, 2009
Virtual Issues
Vol. 4, Iss. 9 Virtual Journal for Biomedical Optics
Citation
Brian G. Saar, Gary R. Holtom, Christian W. Freudiger, Chrisita Ackermann, Winfield Hill, and X. Sunney Xie, "Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy," Opt. Express 17, 12532-12539 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-15-12532
Sort: Year | Journal | Reset
References
- G. C. Bjorklund, “Frequency-modulation spectroscopy: a new method for measuring weak absorptions and dispersions,” Opt. Lett. 5(1), 15 (1980). [CrossRef] [PubMed]
- B. Levine, C. Shank, and J. Heritage, “Surface vibrational spectroscopy using stimulated Raman scattering,” IEEE J. Quantum Electron. 15(12), 1418–1432 (1979). [CrossRef]
- M. D. Levenson, W. E. Moerner, and D. E. Horne, “FM spectroscopy detection of stimulated Raman gain,” Opt. Lett. 8(2), 108–110 (1983). [CrossRef] [PubMed]
- W. E. Moerner and L. Kador, “Optical detection and spectroscopy of single molecules in a solid,” Phys. Rev. Lett. 62(21), 2535–2538 (1989). [CrossRef] [PubMed]
- C. L. Evans and X. S. Xie, “Coherent Anti-Stokes Raman Scattering Microscopy: Chemical Imaging for Biology and Medicine,” Annu. Rev. Anal. Chem. 1(1), 883–909 (2008). [CrossRef]
- C. W. Freudiger, W. Min, B. G. Saar, S. Lu, G. R. Holtom, C. He, J. C. Tsai, J. X. Kang, and X. S. Xie, “Label-free biomedical imaging with high sensitivity by stimulated Raman scattering microscopy,” Science 322(5909), 1857–1861 (2008). [CrossRef] [PubMed]
- F. Ganikhanov, C. L. Evans, B. G. Saar, and X. S. Xie, “High-sensitivity vibrational imaging with frequency modulation coherent anti-Stokes Raman scattering (FM CARS) microscopy,” Opt. Lett. 31(12), 1872–1874 (2006). [CrossRef] [PubMed]
- M. C. Fischer, H. Liu, I. R. Piletic, T. Ye, R. Yasuda, and W. S. Warren, “Self-phase modulation and two-photon absorption imaging of cells and active neurons,” Proc. SPIE 6442, 64421J (2007). [CrossRef]
- D. J. Jones, E. O. Potma, J.-X. Cheng, B. Burfeindt, Y. Pang, J. Ye, and X. S. Xie, “Synchronization of two passively mode-locked, picosecond lasers within 20 fs for coherent anti-Stokes Raman scattering microscopy,” Rev. Sci. Instrum. 73(8), 2843–2848 (2002). [CrossRef]
- W. Demtröder, Laser Spectroscopy, 3rd ed. (Springer-Verlag, New York, 2003).
- C. L. Tang and J. M. Telle, “Laser modulation spectroscopy of solids,” J. Appl. Phys. 45(10), 4503–4505 (1974). [CrossRef]
- J. M. Telle and C. L. Tang, “New method for electro-optical tuning of tunable lasers,” Appl. Phys. Lett. 24(2), 85–87 (1974). [CrossRef]
- L. Cabaret, P. Camus, R. Leroux, and J. Philip, “Intracavity LiNbO(3) Fabry-Perot etalon for frequency stabilization and tuning of a single-mode quasi-continuous-wave titanium:sapphire ring laser,” Opt. Lett. 26(13), 983–985 (2001). [CrossRef]
- H. F. Gleeson, A. J. Murray, E. Fraser, and A. Zoro, “An electrically addressed liquid crystal filter for tunable lasers,” Opt. Commun. 212(1-3), 165–168 (2002). [CrossRef]
- A. Godard and E. Rosencher, “Energy yield of pulsed optical parametric oscillators: a rate-equation analysis,” IEEE J. Quantum Electron. 40(6), 784–790 (2004). [CrossRef]
- X. S. Xie, J. Yu, and W. Y. Yang, “Living cells as test tubes,” Science 312(5771), 228–230 (2006). [CrossRef] [PubMed]
Cited By |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.





OSA is a member of 