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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 21 — Oct. 12, 2009
  • pp: 19041–19046

Nanoparticle enhanced surface plasmon resonance biosensing: Application of gold nanorods

Wing-Cheung Law, Ken-Tye Yong, Alexander Baev, Rui Hu, and Paras N. Prasad  »View Author Affiliations


Optics Express, Vol. 17, Issue 21, pp. 19041-19046 (2009)
http://dx.doi.org/10.1364/OE.17.019041


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Abstract

In this report, we demonstrate the use of functionalized gold nanorods as amplification labels for ultra-sensitive surface plasmon resonance biosensing. Drastic sensitivity enhancement, owed to the electromagnetic interaction between the nanotag and the sensing film, was maximized using longitudinal plasmonic resonance of gold nanorods. The detection sensitivity of the nanorod-conjugated antibody is estimated to be ~40 pg/ml, which is 25 – 100 times more sensitive than the current reported values in the literature. This work paves the way to a new generation of ultra-sensitive nanoparticles-based biosensor platforms with maximized enhancement of sensitivity for ultra-fast screening and real-time detection of “hard-to-identify” biomolecules.

© 2009 OSA

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:
Optics at Surfaces

History
Original Manuscript: August 7, 2009
Revised Manuscript: September 4, 2009
Manuscript Accepted: September 8, 2009
Published: October 7, 2009

Virtual Issues
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Wing-Cheung Law, Ken-Tye Yong, Alexander Baev, Rui Hu, and Paras N. Prasad, "Nanoparticle enhanced surface plasmon resonance biosensing: Application of gold nanorods," Opt. Express 17, 19041-19046 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-21-19041


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