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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 23 — Nov. 9, 2009
  • pp: 20771–20776

A generalized model of maximizing the sensitivity in intensity-interrogation surface plasmon resonance biosensors

Chung-Tien Li, Ta-Jen Yen, and How-foo Chen  »View Author Affiliations

Optics Express, Vol. 17, Issue 23, pp. 20771-20776 (2009)

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Intensity interrogation of surface plasmon resonance (IISPR) biosensors possesses the greatest sensitivity beyond other interrogations and is operated at a fixed incident angle to enable real-time analysis without time delay, so that it promises excellent performance in biological/chemical detection and SPR imaging systems. Here we provide a general model to describe its sensitivity based on Lorentz equation and unveil the relation between the sensitivity and the metal thickness. This model presents the dependency between sensitivity and metal thickness, and the optimal thickness of gold layers to maximize the sensitivity in our experiment is 53 nm that agrees well in both measurement and simulation. This general model can be further applied in other intensity-interrogation SPR configurations as a design rule for sensing and imaging applications.

© 2009 OSA

OCIS Codes
(000.4430) General : Numerical approximation and analysis
(130.6010) Integrated optics : Sensors
(240.0310) Optics at surfaces : Thin films
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:

Original Manuscript: September 8, 2009
Revised Manuscript: October 22, 2009
Manuscript Accepted: October 23, 2009
Published: October 28, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Chung-Tien Li, Ta-Jen Yen, and How-foo Chen, "A generalized model of maximizing the sensitivity in intensity-interrogation surface plasmon resonance biosensors," Opt. Express 17, 20771-20776 (2009)

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