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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 17, Iss. 24 — Nov. 23, 2009
  • pp: 21634–21651

Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics

Barry Cense, Weihua Gao, Jeffrey M. Brown, Steven M. Jones, Ravi S. Jonnal, Mircea Mujat, B. Hyle Park, Johannes F. de Boer, and Donald T. Miller  »View Author Affiliations


Optics Express, Vol. 17, Issue 24, pp. 21634-21651 (2009)
http://dx.doi.org/10.1364/OE.17.021634


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Abstract

Various layers of the retina are well known to alter the polarization state of light. Such changes in polarization may be a sensitive indicator of tissue structure and function, and as such have gained increased clinical attention. Here we demonstrate a polarization-sensitive optical coherence tomography (PS-OCT) system that incorporates adaptive optics (AO) in the sample arm and a single line scan camera in the detection arm. We quantify the benefit of AO for PS-OCT in terms of signal-to-noise, lateral resolution, and speckle size. Double pass phase retardation per unit depth values ranging from 0.25°/μm to 0.65°/μm were found in the birefringent nerve fiber layer at 6° eccentricity, superior to the fovea, with the highest values being noticeably higher than previously reported with PS-OCT around the optic nerve head. Moreover, fast axis orientation and degree of polarization uniformity measurements made with AO-PS-OCT demonstrate polarization scrambling in the retinal pigment epithelium at the highest resolution reported to date.

© 2009 OSA

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 10, 2009
Revised Manuscript: November 4, 2009
Manuscript Accepted: November 6, 2009
Published: November 11, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Barry Cense, Weihua Gao, Jeffrey M. Brown, Steven M. Jones, Ravi S. Jonnal, Mircea Mujat, B. Hyle Park, Johannes F. de Boer, and Donald T. Miller, "Retinal imaging with polarization-sensitive optical coherence tomography and adaptive optics," Opt. Express 17, 21634-21651 (2009)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-17-24-21634


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