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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 14 — Jul. 5, 2010
  • pp: 14353–14358

Self-noise-filtering phase-sensitive surface plasmon resonance biosensing

Sergiy Patskovsky, Michel Meunier, Paras N. Prasad, and Andrei V. Kabashin  »View Author Affiliations

Optics Express, Vol. 18, Issue 14, pp. 14353-14358 (2010)

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Emerged as an upgrade of currently available Surface Plasmon Resonance (SPR) biosensing in terms of sensitivity, phase-sensitive SPR technology still requires the minimization of instrumental noises to profit from its projected ultra-low detection limit (10−8 refractive index units and lower). We present a polarimetry-based methodology for the efficient reduction of main instrumental noises in phase-sensitive measurements. The proposed approach employs a sinusoidal phase modulation of pumping light and is based on selection of proper modulation amplitude and initial phase relation for the first two modulation harmonics (F1 and F2), which enables to subtract amplitude drifts in the difference (F1 - F2) signal while doubling the phase response. The resulting effect can be called self-noise-filtering, since it implies an inherent noise subtraction in every phase sensing measurement. This methodology allows one to tackle drifts related to instabilities of light sources and optical elements and thus drastically lower the detection limit of phase-sensitive SPR sensing even in relatively simple and noisy experimental implementations.

© 2010 OSA

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(240.6680) Optics at surfaces : Surface plasmons

ToC Category:

Original Manuscript: April 29, 2010
Revised Manuscript: June 6, 2010
Manuscript Accepted: June 7, 2010
Published: June 21, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Sergiy Patskovsky, Michel Meunier, Paras N. Prasad, and Andrei V. Kabashin, "Self-noise-filtering phase-sensitive surface plasmon resonance biosensing," Opt. Express 18, 14353-14358 (2010)

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