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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 14 — Jul. 5, 2010
  • pp: 15256–15266

An open-source toolkit for the volumetric measurement of CT lung lesions

Karthik Krishnan, Luis Ibanez, Wesley D. Turner, Julien Jomier, and Ricardo S. Avila  »View Author Affiliations

Optics Express, Vol. 18, Issue 14, pp. 15256-15266 (2010)

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An open source lesion sizing toolkit has been developed with a general architecture for implementing lesion segmentation algorithms and a reference algorithm for segmenting solid and part-solid lesions from lung CT scans. The CT lung lesion segmentation algorithm detects four three-dimensional features corresponding to the lung wall, vasculature, lesion boundary edges, and low density background lung parenchyma. These features form boundaries and propagation zones that guide the evolution of a subsequent level set algorithm. User input is used to determine an initial seed point for the level set and users may also define a region of interest around the lesion. The methods are validated against 18 nodules using CT scans of an anthropomorphic thorax phantom simulating lung anatomy. The scans were acquired under differing scanner parameters to characterize algorithm behavior under varying acquisition protocols. We also validated repeatability using six clinical cases in which the patient was rescanned on the same day (zero volume change). The source code, data sets, and a running application are all provided under an unrestrictive license to encourage reproducibility and foster scientific exchange.

© 2010 OSA

OCIS Codes
(100.6890) Image processing : Three-dimensional image processing
(110.2960) Imaging systems : Image analysis

Original Manuscript: January 20, 2010
Revised Manuscript: June 28, 2010
Manuscript Accepted: June 30, 2010
Published: July 2, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics
Imaging in Diagnosis and Treatment of Lung Cancer (2010) Optics Express

Karthik Krishnan, Luis Ibanez, Wesley D. Turner, Julien Jomier, and Ricardo S. Avila, "An open-source toolkit for the volumetric measurement of CT lung lesions," Opt. Express 18, 15256-15266 (2010)

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