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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 21 — Oct. 11, 2010
  • pp: 21612–21621

Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues

Robert H. Wilson, Malavika Chandra, Leng-Chun Chen, William R. Lloyd, James Scheiman, Diane Simeone, Julianne Purdy, Barbara McKenna, and Mary-Ann Mycek  »View Author Affiliations


Optics Express, Vol. 18, Issue 21, pp. 21612-21621 (2010)
http://dx.doi.org/10.1364/OE.18.021612


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Abstract

A photon-tissue interaction (PTI) model was developed and employed to analyze 96 pairs of reflectance and fluorescence spectra from freshly excised human pancreatic tissues. For each pair of spectra, the PTI model extracted a cellular nuclear size parameter from the measured reflectance, and the relative contributions of extracellular and intracellular fluorophores to the intrinsic fluorescence. The results suggest that reflectance and fluorescence spectroscopies have the potential to quantitatively distinguish among pancreatic tissue types, including normal pancreatic tissue, pancreatitis, and pancreatic adenocarcinoma.

© 2010 OSA

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: June 16, 2010
Revised Manuscript: September 22, 2010
Manuscript Accepted: September 23, 2010
Published: September 28, 2010

Virtual Issues
Vol. 5, Iss. 14 Virtual Journal for Biomedical Optics

Citation
Robert H. Wilson, Malavika Chandra, Leng-Chun Chen, William R. Lloyd, James Scheiman, Diane Simeone, Julianne Purdy, Barbara McKenna, and Mary-Ann Mycek, "Photon-tissue interaction model enables quantitative optical analysis of human pancreatic tissues," Opt. Express 18, 21612-21621 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-21-21612


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