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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 24 — Nov. 22, 2010
  • pp: 24565–24578

Experimental demonstration of an Optical-Sectioning Compressive Sensing Microscope (CSM)

Yuehao Wu, Peng Ye, Iftekhar O. Mirza, Gonzalo R. Arce, and Dennis W. Prather  »View Author Affiliations


Optics Express, Vol. 18, Issue 24, pp. 24565-24578 (2010)
http://dx.doi.org/10.1364/OE.18.024565


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Abstract

In this paper we present the design and implementation of a Compressive Sensing Microscopy (CSM) imaging system, which uses the Compressive Sensing (CS) method to realize optical-sectioning imaging. The theoretical aspect of the proposed system is investigated using the mathematical model of the CS method and an experimental prototype is constructed to verify the CSM design. Compared to conventional optical-sectioning microscopes (such as Laser Scanning Confocal Microscopes (LSCMs) or Programmable Array Microscopes (PAMs)), the CSM system realizes optical-sectioning imaging using a single-pixel photo detector and without any mechanical scanning process. The complete information of the imaging scene is reconstructed from the CS measurements numerically.

© 2010 OSA

OCIS Codes
(110.0110) Imaging systems : Imaging systems
(180.1790) Microscopy : Confocal microscopy
(180.2520) Microscopy : Fluorescence microscopy

ToC Category:
Microscopy

History
Original Manuscript: August 9, 2010
Revised Manuscript: October 13, 2010
Manuscript Accepted: October 30, 2010
Published: November 10, 2010

Citation
Yuehao Wu, Peng Ye, Iftekhar O. Mirza, Gonzalo R. Arce, and Dennis W. Prather, "Experimental demonstration of an Optical-Sectioning Compressive Sensing Microscope (CSM)," Opt. Express 18, 24565-24578 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-24-24565


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References

  1. J. A. Conchello and J. W. Lichtman, “Optical sectioning microscopy,” Nat. Methods 2(12), 920–931 (2005). [CrossRef] [PubMed]
  2. M. Liang, R. L. Stehr, and A. W. Krause, “Confocal pattern period in multiple-aperture confocal imaging systems with coherent illumination,” Opt. Lett. 22(11), 751–753 (1997). [CrossRef] [PubMed]
  3. Q. S. Hanley, P. J. Verveer, M. J. Gemkow, D. Arndt-Jovin, and T. M. Jovin, “An optical sectioning programmable array microscope implemented with a digital micromirror device,” J. Microsc. 196(3), 317–331 (1999). [CrossRef] [PubMed]
  4. Q. S. Hanley, D. Verveer, and T. M. Jovin, “Optical-sectioning fluorescence spectroscopy in a programmable array microscope,” Appl. Spectrosc. 52(6), 783–792 (1998). [CrossRef]
  5. E. Candès and M. Wakin, “An introduction to compressive sampling,” IEEE Signal Process. Mag. 25(2), 21–30 (2008). [CrossRef]
  6. E. Candès, “Compressive sampling,” Proc. Int. Congress of Mathematics 3, 1433–1452, Madrid, Spain, (2006).
  7. M. Lustig, D. Donoho, and J. M. Pauly, “Sparse MRI: The application of compressed sensing for rapid MR imaging,” Magn. Reson. Med. 58(6), 1182–1195 (2007). [CrossRef] [PubMed]
  8. R. G. Baraniuk, “Compressive Sensing,” IEEE Signal Process. Mag. 24(4), 118–121 (2007). [CrossRef]
  9. M. F. Duarte, M. A. Davenport, D. Takhar, J. N. Laska, K. F. Ting Sun, Kelly, and R. G. Baraniuk, “Single-Pixel Imaging via Compressive Sampling,” IEEE Signal Process. Mag. 25(2), 83–91 (2008). [CrossRef]
  10. Y. Wu, P. Ye, Z. Wang, G. R. Arce, and D. W. Prather, “A Single-Pixel Optical Sectioning Programmable Array Microscope (SP-PAM),” Proc. SPIE 7596, 75960D (2010). [CrossRef]
  11. P. Ye, J. L. Paredes, Y. Wu, C. Chen, G. R. Arce, and D. W. Prather, “Compressive confocal microscopy: 3D reconstruction algorithms,” Proc. SPIE 7210, 72100G (2009). [CrossRef]
  12. S. J. Kim, K. Koh, M. Lustig, S. Boyd, and D. Gorinevsky, “A method for large-scale l1- regularized least squares,” IEEE J. STSP 1(4), 606–617 (2007).
  13. D. Dudley, W. Duncan, and J. Slaughter, “Emerging digital micromirror device (DMD) applications,” Proc. SPIE 4985, 14 (2003). [CrossRef]
  14. J. W. Goodman, Introduction to Fourier Optics, 3rd Edition (Roberts & Company Publishers, 2004), Chap. 6.

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