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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 3 — Feb. 1, 2010
  • pp: 2782–2796

Optical distortion correction in Optical Coherence Tomography for quantitative ocular anterior segment by three-dimensional imaging

Sergio Ortiz, Damian Siedlecki, Ireneusz Grulkowski, Laura Remon, Daniel Pascual, Maciej Wojtkowski, and Susana Marcos  »View Author Affiliations


Optics Express, Vol. 18, Issue 3, pp. 2782-2796 (2010)
http://dx.doi.org/10.1364/OE.18.002782


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Abstract

A method for three-dimensional 3-D optical distortion (refraction) correction on anterior segment Optical Coherence Tomography (OCT) images has been developed. The method consists of 3-D ray tracing through the different surfaces, following denoising, segmentation of the surfaces, Delaunay representation of the surfaces, and application of fan distortion correction. The correction has been applied theoretically to realistic computer eye models, and experimentally to OCT images of: an artificial eye with a Polymethyl Methacrylate (PMMA) cornea and an intraocular lens (IOL), an enucleated porcine eye, and a human eye in vivo obtained from two OCT laboratory set-ups (time domain and spectral). Data are analyzed in terms of surface radii of curvature and asphericity. Comparisons are established between the reference values for the surfaces (nominal values in the computer model; non-contact profilometric measurements for the artificial eye; Scheimpflug imaging for the real eyes in vivo and vitro). The results from the OCT data were analyzed following the conventional approach of dividing the optical path by the refractive index, after application of 2-D optical correction, and 3-D optical correction (in all cases after fan distortion correction). The application of 3-D optical distortion correction increased significantly both the accuracy of the radius of curvature estimates and particularly asphericity of the surfaces, with respect to conventional methods of OCT image analysis. We found that the discrepancies of the radii of curvature estimates from 3-D optical distortion corrected OCT images are less than 1% with respect to nominal values. Optical distortion correction in 3-D is critical for quantitative analysis of OCT anterior segment imaging, and allows accurate topography of the internal surfaces of the eye.

© 2010 OSA

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.4640) Instrumentation, measurement, and metrology : Optical instruments
(120.4800) Instrumentation, measurement, and metrology : Optical standards and testing
(120.6650) Instrumentation, measurement, and metrology : Surface measurements, figure
(330.7327) Vision, color, and visual optics : Visual optics, ophthalmic instrumentation

ToC Category:
Imaging Systems

History
Original Manuscript: November 13, 2009
Revised Manuscript: December 30, 2009
Manuscript Accepted: January 5, 2010
Published: January 26, 2010

Virtual Issues
Vol. 5, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Sergio Ortiz, Damian Siedlecki, Ireneusz Grulkowski, Laura Remon, Daniel Pascual, Maciej Wojtkowski, and Susana Marcos, "Optical distortion correction in Optical Coherence Tomography for quantitative ocular anterior segment by three-dimensional imaging," Opt. Express 18, 2782-2796 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-3-2782


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