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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 7 — Mar. 29, 2010
  • pp: 7203–7209

High throughput and wide field of view EUV microscope for blur-free one-shot imaging of living organisms

Takeo Ejima, Fumihiko Ishida, Hiromichi Murata, Mitsunori Toyoda, Tetsuo Harada, Toshihide Tsuru, Tadashi Hatano, Mihiro Yanagihara, Masaki Yamamoto, and Haruo Mizutani  »View Author Affiliations


Optics Express, Vol. 18, Issue 7, pp. 7203-7209 (2010)
http://dx.doi.org/10.1364/OE.18.007203


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Abstract

We present and demonstrate the use of an extreme ultraviolet (EUV) microscope that was developed in-house. Images are acquired using Bragg reflection multilayer optics and a laser-produced plasma light source. The upper-limit spatial resolution of the EUV microscope is 130 nm with a 10 ns exposure time and 250 × 250 μm2 field of view. Resolution is superior to that of visible microscopes with the same size of field of view, and the exposure time is short enough to observe fine structures in-vivo. Observation of the cerebral cortex of a mouse is demonstrated.

© 2010 OSA

OCIS Codes
(110.0180) Imaging systems : Microscopy
(110.7440) Imaging systems : X-ray imaging
(180.7460) Microscopy : X-ray microscopy
(230.4170) Optical devices : Multilayers
(340.7460) X-ray optics : X-ray microscopy
(340.7480) X-ray optics : X-rays, soft x-rays, extreme ultraviolet (EUV)

ToC Category:
X-ray Optics

History
Original Manuscript: December 7, 2009
Revised Manuscript: February 19, 2010
Manuscript Accepted: March 11, 2010
Published: March 24, 2010

Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Takeo Ejima, Fumihiko Ishida, Hiromichi Murata, Mitsunori Toyoda, Tetsuo Harada, Toshihide Tsuru, Tadashi Hatano, Mihiro Yanagihara, Masaki Yamamoto, and Haruo Mizutani, "High throughput and wide field of view EUV microscope for blur-free one-shot imaging of living organisms," Opt. Express 18, 7203-7209 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-7-7203


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References

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