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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 18, Iss. 8 — Apr. 12, 2010
  • pp: 8193–8206

Integrated optical frequency-resolved Mach-Zehnder interferometers for label-free affinity sensing

Maria Kitsara, Konstantinos Misiakos, Ioannis Raptis, and Eleni Makarona  »View Author Affiliations


Optics Express, Vol. 18, Issue 8, pp. 8193-8206 (2010)
http://dx.doi.org/10.1364/OE.18.008193


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Abstract

Integrated Optical Frequency-Resolved Mach-Zehnder Interferometry (IO FR-MZI) is introduced as an alternative, cost-efficient operation principle for integrated optical label-free affinity sensors that can combine high sensitivity with high versatility in terms of potential applications and experimental configurations. A detailed theoretical analysis of the method is presented followed by a semi-analytical approximation and numerical calculations in order to quantify the sensitivity and limits of detection of the FR-MZI over Single Wavelength MZI. The obtained results substantiate that IO FR-MZI- based sensors constitute a generic technological platform of high sensitivity that can be implemented into a plethora of detection schemes. For an optimized optical design well below 1mm in length the limit of detection can be as low as 0.025Å in terms of adlayer effective thickness allowing for truly miniaturized integrated optical sensors fabricated with high yield with standard microfabrication techniques.

© 2010 OSA

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(130.3120) Integrated optics : Integrated optics devices

ToC Category:
Integrated Optics

History
Original Manuscript: February 8, 2010
Revised Manuscript: March 16, 2010
Manuscript Accepted: March 16, 2010
Published: April 2, 2010

Citation
Maria Kitsara, Konstantinos Misiakos, Ioannis Raptis, and Eleni Makarona, "Integrated optical frequency-resolved Mach-Zehnder interferometers for label-free affinity sensing," Opt. Express 18, 8193-8206 (2010)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-18-8-8193


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