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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 11 — May. 23, 2011
  • pp: 10747–10761

Multi-modality optical neural imaging using coherence control of VCSELs

Elizabeth A. Munro, Hart Levy, Dene Ringuette, Thomas D. O’Sullivan, and Ofer Levi  »View Author Affiliations

Optics Express, Vol. 19, Issue 11, pp. 10747-10761 (2011)

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Abstract: Neural optical imaging can evaluate cortical hemodynamic fluctuations which reflect neural activity and disease state. We evaluate the use of vertical-cavity surface-emitting lasers (VCSELs) as illumination source for simultaneous imaging of blood flow and tissue oxygenation dynamics ex vivo and in vivo and demonstrate optical imaging of blood flow changes and oxygenation changes in response to induced ischemia. Using VCSELs we show a rapid switching from a single-mode to a special multi-mode rapid current sweep operation and noise values reduced to within a factor of 40% compared to non-coherent LED illumination. These VCSELs are promising for long-term portable continuous monitoring of brain dynamics in freely moving animals.

© 2011 OSA

OCIS Codes
(140.2020) Lasers and laser optics : Diode lasers
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6480) Medical optics and biotechnology : Spectroscopy, speckle

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: February 4, 2011
Revised Manuscript: May 10, 2011
Manuscript Accepted: May 16, 2011
Published: May 18, 2011

Virtual Issues
Vol. 6, Iss. 6 Virtual Journal for Biomedical Optics

Elizabeth A. Munro, Hart Levy, Dene Ringuette, Thomas D. O’Sullivan, and Ofer Levi, "Multi-modality optical neural imaging using coherence control of VCSELs," Opt. Express 19, 10747-10761 (2011)

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