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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 16 — Aug. 1, 2011
  • pp: 15244–15254

Monitoring of heparin concentration in serum by Raman spectroscopy within hollow core photonic crystal fiber

Altaf Khetani, Vidhu S. Tiwari, Alaa Harb, and Hanan Anis  »View Author Affiliations


Optics Express, Vol. 19, Issue 16, pp. 15244-15254 (2011)
http://dx.doi.org/10.1364/OE.19.015244


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Abstract

The feasibility of using hollow core photonic crystal fiber (HC-PCF) in conjunction with Raman spectroscopy has been explored for real time monitoring of heparin concentration in serum. Heparin is an important blood anti-coagulant whose precise monitoring and controlling in patients undergoing cardiac surgery and dialysis is of utmost importance. Our method of heparin monitoring offers a novel alternative to existing clinical procedures in terms of accuracy, response time and sample volume. The optical design configuration simply involves a 785-nm laser diode whose light is coupled into HC-PCF filled with heparin-serum mixtures. By non-selectively filling HC-PCF, a strong modal field overlap is obtained. Consequently, an enhanced Raman signal (>90 times) is obtained from various heparin-serum mixtures filled HC-PCFs compared to its bulk counterpart (cuvette). The present scheme has the potential to serve as a ‘generic biosensing tool’ for diagnosing a wide range of biological samples.

© 2011 OSA

OCIS Codes
(170.5660) Medical optics and biotechnology : Raman spectroscopy
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(060.5295) Fiber optics and optical communications : Photonic crystal fibers

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: May 27, 2011
Revised Manuscript: July 11, 2011
Manuscript Accepted: July 20, 2011
Published: July 25, 2011

Virtual Issues
Vol. 6, Iss. 9 Virtual Journal for Biomedical Optics

Citation
Altaf Khetani, Vidhu S. Tiwari, Alaa Harb, and Hanan Anis, "Monitoring of heparin concentration in serum by Raman spectroscopy within hollow core photonic crystal fiber," Opt. Express 19, 15244-15254 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-16-15244


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References

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