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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 22 — Oct. 24, 2011
  • pp: 21552–21562

High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model

Hua Chen, Te-Hsuen Chen, Tzu-Fang Tseng, Jen-Tang Lu, Chung-Chiu Kuo, Shih-Chen Fu, Wen-Jeng Lee, Yuan-Fu Tsai, Yi-You Huang, Eric Y. Chuang, Yuh-Jing Hwang, and Chi-Kuang Sun  »View Author Affiliations


Optics Express, Vol. 19, Issue 22, pp. 21552-21562 (2011)
http://dx.doi.org/10.1364/OE.19.021552


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Abstract

We performed in vivo THz transmission imaging study on a subcutaneous xenograft mouse model for early human breast cancer detection. With a THz-fiber-scanning transmission imaging system, we continuously monitored the growth of human breast cancer in mice. Our in vivo study not only indicates that THz transmission imaging can distinguish cancer from the surrounding fatty tissue, but also with a high sensitivity. Our in vivo study on the subcutaneous xenograft mouse model will encourage broad and further investigations for future early cancer screening by using THz imaging system.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(110.6795) Imaging systems : Terahertz imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 18, 2011
Revised Manuscript: August 19, 2011
Manuscript Accepted: September 9, 2011
Published: October 18, 2011

Virtual Issues
Vol. 6, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Hua Chen, Te-Hsuen Chen, Tzu-Fang Tseng, Jen-Tang Lu, Chung-Chiu Kuo, Shih-Chen Fu, Wen-Jeng Lee, Yuan-Fu Tsai, Yi-You Huang, Eric Y. Chuang, Yuh-Jing Hwang, and Chi-Kuang Sun, "High-sensitivity in vivo THz transmission imaging of early human breast cancer in a subcutaneous xenograft mouse model," Opt. Express 19, 21552-21562 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-22-21552


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