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Optics Express

Optics Express

  • Editor: C. Martijin de Sterke
  • Vol. 19, Iss. 7 — Mar. 28, 2011
  • pp: 6131–6140

Determination of the scattering anisotropy with optical coherence tomography

V. M. Kodach, D. J. Faber, J. van Marle, T. G. van Leeuwen, and J. Kalkman  »View Author Affiliations

Optics Express, Vol. 19, Issue 7, pp. 6131-6140 (2011)

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In this work we demonstrate measurements with optical coherence tomography (OCT) of the scattering phase function in the backward direction and the scattering anisotropy parameter g. Measurements of the OCT attenuation coefficient and the backscattering amplitude are performed on calibrated polystyrene microspheres with a time-domain OCT system. From these measurements the phase function in the backward direction is determined. The measurements are described by the single scattering model and match Mie calculations very well. Measurements on Intralipid demonstrate the ability to determine the g of polydisperse samples and, for Intralipid, g = 0.35 ± 0.03 is measured, which is well in agreement with g from literature. These measurements are validated using the Intralipid particle size distribution determined from TEM measurements. Measurements of g and the scattering phase function in the backward direction can be used to monitor changes in backscattering, which can indicate morphological changes of the sample or act as contrast enhancement mechanism.

© 2011 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(290.7050) Scattering : Turbid media

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 19, 2011
Revised Manuscript: March 1, 2011
Manuscript Accepted: March 3, 2011
Published: March 17, 2011

Virtual Issues
Vol. 6, Iss. 4 Virtual Journal for Biomedical Optics

V. M. Kodach, D. J. Faber, J. van Marle, T. G. van Leeuwen, and J. Kalkman, "Determination of the scattering anisotropy with optical coherence tomography," Opt. Express 19, 6131-6140 (2011)

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