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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 19, Iss. 8 — Apr. 11, 2011
  • pp: 7410–7416

Polarimetric total internal reflection biosensing

Mathieu Maisonneuve, In-Hyouk Song, Sergiy Patskovsky, and Michel Meunier  »View Author Affiliations


Optics Express, Vol. 19, Issue 8, pp. 7410-7416 (2011)
http://dx.doi.org/10.1364/OE.19.007410


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Abstract

In this paper, a concept of polarimetric total internal reflection (TIR) biosensor based on the method of temporal phase modulation is presented. Measurements of the phase difference between s- and p- polarized light combined with their amplitudes allow simultaneous detection of the bulk refractive index and thickness of the surface biofilms. Obtained experimental sensitivity is better than 10−5 in terms of refractive index unit and 0.5 nm in biolayer thickness. Relatively simple technological implementation of the TIR sensors on the base of inexpensive and transparent substrates opens a number of novel applications in biosensing and microscopy.

© 2011 OSA

OCIS Codes
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(240.2130) Optics at surfaces : Ellipsometry and polarimetry

ToC Category:
Sensors

History
Original Manuscript: December 8, 2010
Revised Manuscript: January 18, 2011
Manuscript Accepted: March 17, 2011
Published: April 4, 2011

Virtual Issues
Vol. 6, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Mathieu Maisonneuve, In-Hyouk Song, Sergiy Patskovsky, and Michel Meunier, "Polarimetric total internal reflection biosensing," Opt. Express 19, 7410-7416 (2011)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-19-8-7410


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