OSA's Digital Library

Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 1 — Jan. 2, 2012
  • pp: 672–680

High-resolution biosensor based on localized surface plasmons

Marek Piliarik, Hana Šípová, Pavel Kvasnička, Nicolle Galler, Joachim R. Krenn, and Jiří Homola  »View Author Affiliations


Optics Express, Vol. 20, Issue 1, pp. 672-680 (2012)
http://dx.doi.org/10.1364/OE.20.000672


View Full Text Article

Enhanced HTML    Acrobat PDF (949 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We report on a new biosensor with localized surface plasmons (LSP) based on an array of gold nanorods and the total internal reflection imaging in polarization contrast. The sensitivity of the new biosensor is characterized and a model detection of DNA hybridization is carried out. The results are compared with a reference experiment using a conventional high-resolution surface plasmon resonance (SPR) biosensor. We show that the LSP-based biosensor delivers the same performance as the SPR system while involving significantly lower surface densities of interacting molecules. We demonstrate a limit of detection of 100 pM and a surface density resolution of only 35 fg×mm−2 that corresponds to less than one DNA molecule per nanoparticle on average.

© 2011 OSA

OCIS Codes
(240.6680) Optics at surfaces : Surface plasmons
(280.4788) Remote sensing and sensors : Optical sensing and sensors
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:
Sensors

History
Original Manuscript: November 2, 2011
Revised Manuscript: December 5, 2011
Manuscript Accepted: December 10, 2011
Published: December 23, 2011

Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Marek Piliarik, Hana Šípová, Pavel Kvasnička, Nicolle Galler, Joachim R. Krenn, and Jiří Homola, "High-resolution biosensor based on localized surface plasmons," Opt. Express 20, 672-680 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-1-672


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev.108(2), 462–493 (2008). [CrossRef] [PubMed]
  2. B. Sepúlveda, P. C. Angelome, L. M. Lechuga, and L. M. Liz-Marzan, “LSPR-based nanobiosensors,” Nano Today4(3), 244–251 (2009). [CrossRef]
  3. P. Kvasnička and J. Homola, “Optical sensors based on spectroscopy of localized surface plasmons on metallic nanoparticles: sensitivity considerations,” Biointerphases3(3), FD4–FD11 (2008). [CrossRef] [PubMed]
  4. K. M. Mayer, F. Hao, S. Lee, P. Nordlander, and J. H. Hafner, “A single molecule immunoassay by localized surface plasmon resonance,” Nanotechnology21(25), 255503 (2010). [CrossRef] [PubMed]
  5. H. W. Huang, C. R. Tang, Y. L. Zeng, X. Y. Yu, B. Liao, X. D. Xia, P. G. Yi, and P. K. Chu, “Label-free optical biosensor based on localized surface plasmon resonance of immobilized gold nanorods,” Colloids Surf., B71(1), 96–101 (2009). [CrossRef] [PubMed]
  6. J. X. Fu, B. Park, and Y. P. Zhao, “Nanorod-mediated surface plasmon resonance sensor based on effective medium theory,” Appl. Opt.48(23), 4637–4649 (2009). [CrossRef] [PubMed]
  7. M. D. Arnold, M. G. Blaber, M. J. Ford, and N. Harris, “Universal scaling of local plasmons in chains of metal spheres,” Opt. Express18(7), 7528–7542 (2010). [CrossRef] [PubMed]
  8. E. Petryayeva and U. J. Krull, “Localized surface plasmon resonance: nanostructures, bioassays and biosensing--a review,” Anal. Chim. Acta706(1), 8–24 (2011). [CrossRef] [PubMed]
  9. S. Chen, M. Svedendahl, M. Käll, L. Gunnarsson, and A. Dmitriev, “Ultrahigh sensitivity made simple: nanoplasmonic label-free biosensing with an extremely low limit-of-detection for bacterial and cancer diagnostics,” Nanotechnology20(43), 434015 (2009). [CrossRef] [PubMed]
  10. A. B. Dahlin, J. O. Tegenfeldt, and F. Höök, “Improving the instrumental resolution of sensors based on localized surface plasmon resonance,” Anal. Chem.78(13), 4416–4423 (2006). [CrossRef] [PubMed]
  11. M. Piliarik, P. Kvasnička, N. Galler, J. R. Krenn, and J. Homola, “Local refractive index sensitivity of plasmonic nanoparticles,” Opt. Express19(10), 9213–9220 (2011). [CrossRef] [PubMed]
  12. M. Piliarik, L. Párová, and J. Homola, “High-throughput SPR sensor for food safety,” Biosens. Bioelectron.24(5), 1399–1404 (2009). [CrossRef] [PubMed]
  13. M. Piliarik, H. Vaisocherova, and J. Homola, “Towards parallelized surface plasmon resonance sensor platform for sensitive detection of oligonucleotides,” Sens. Actuators B Chem.121(1), 187–193 (2007). [CrossRef]
  14. M. Svedendahl, S. Chen, A. Dmitriev, and M. Käll, “Refractometric sensing using propagating versus localized surface plasmons: a direct comparison,” Nano Lett.9(12), 4428–4433 (2009). [CrossRef] [PubMed]
  15. M. Piliarik and J. Homola, “Surface plasmon resonance (SPR) sensors: approaching their limits?” Opt. Express17(19), 16505–16517 (2009). [CrossRef] [PubMed]
  16. B. Lamprecht, G. Schider, R. T. Lechner, H. Ditlbacher, J. R. Krenn, A. Leitner, and F. R. Aussenegg, “Metal nanoparticle gratings: influence of dipolar particle interaction on the plasmon resonance,” Phys. Rev. Lett.84(20), 4721–4724 (2000). [CrossRef] [PubMed]
  17. J. Homola, Surface Plasmon Resonance Based Sensors (Springer-Verlag, Berlin-Heidelberg-New York, 2006).
  18. H. Vaisocherová, A. Zítová, M. Lachmanová, J. Stepánek, S. Králíková, R. Liboska, D. Rejman, I. Rosenberg, and J. Homola, “Investigating oligonucleotide hybridization at subnanomolar level by surface plasmon resonance biosensor method,” Biopolymers82(4), 394–398 (2006). [CrossRef] [PubMed]
  19. K. M. Mayer and J. H. Hafner, “Localized surface plasmon resonance sensors,” Chem. Rev.111(6), 3828–3857 (2011). [CrossRef] [PubMed]
  20. G. J. Nusz, S. M. Marinakos, A. C. Curry, A. Dahlin, F. Höök, A. Wax, and A. Chilkoti, “Label-free plasmonic detection of biomolecular binding by a single gold nanorod,” Anal. Chem.80(4), 984–989 (2008). [CrossRef] [PubMed]
  21. S. Techane, D. R. Baer, and D. G. Castner, “Simulation and modeling of self-assembled monolayers of carboxylic acid thiols on flat and nanoparticle gold surfaces,” Anal. Chem.83(17), 6704–6712 (2011). [PubMed]
  22. T. Cassier, K. Lowack, and G. Decher, “Layer-by-layer assembled protein/polymer hybrid films: nanoconstruction via specific recognition,” Supramol. Sci.5(3-4), 309–315 (1998). [CrossRef]
  23. A. Rachkov, S. Patskovsky, A. Soldatkin, and M. Meunier, “Surface plasmon resonance detection of oligonucleotide sequences of the rpoB genes of Mycobacterium tuberculosis,” Talanta85(4), 2094–2099 (2011). [CrossRef] [PubMed]
  24. E. Milkani, S. Morais, C. R. Lambert, and W. G. McGimpsey, “Detection of oligonucleotide systematic mismatches with a surface plasmon resonance sensor,” Biosens. Bioelectron.25(5), 1217–1220 (2010). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited