Compressed sensing (CS) can recover sparse signals from under-sampled measurements. In this work, we have developed an advanced CS framework for photoacoustic computed tomography (PACT). During the reconstruction, a small part of the nonzero signals’ locations in the transformed sparse domain is used as partially known support (PKS). PACT reconstructions have been performed with under-sampled in vivo image data of human hands and a rat. Compared to PACT with basic CS, PACT with CS-PKS can recover signals using fewer ultrasonic transducer elements and can improve convergence speed, which may ultimately enable high-speed, low-cost PACT for various biomedical applications.

© 2012 OSA

1. L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012). [CrossRef] [PubMed]
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5. C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev.110(5), 2756–2782 (2010). [CrossRef] [PubMed]
6. Z. X. Xie, W. Roberts, P. Carson, X. Liu, C. Tao, and X. Wang, “Evaluation of bladder microvasculature with high-resolution photoacoustic imaging,” Opt. Lett.36(24), 4815–4817 (2011). [CrossRef] [PubMed]
7. W. Wei, X. Li, Q. F. Zhou, K. K. Shung, and Z. Chen, “Integrated ultrasound and photoacoustic probe for co-registered intravascular imaging,” J. Biomed. Opt.16(10), 106001 (2011). [CrossRef] [PubMed]
8. X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003). [CrossRef] [PubMed]
9. C. H. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt.15(1), 010509 (2010). [CrossRef] [PubMed]
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16. J. Provost and F. Lesage, “The application of compressed sensing for photo-acoustic tomography,” IEEE Trans. Med. Imaging28(4), 585–594 (2009). [CrossRef] [PubMed]
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23. Y. Xu, D. Z. Feng, and L. V. Wang, “Exact frequency-domain reconstruction for thermoacoustic tomography--I: Planar Geometry,” IEEE Trans. Med. Imaging21(7), 823–828 (2002). [CrossRef] [PubMed]
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28. The Laser Institute of America, American National Standard for Safe Use of Lasers, (ANSI Z136.1–2000), The Laser Institute of America (2000).

Appl. Opt.

• G. Ku, X. D. Wang, X. Y. Xie, G. Stoica, and L. V. Wang, “Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography,” Appl. Opt.44(5), 770–775 (2005). [CrossRef] [PubMed]

Chem. Rev.

• C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev.110(5), 2756–2782 (2010). [CrossRef] [PubMed]

IEEE Eng. Med. Biol.

• K. K. Shung and M. Zippuro, “Ultrasonic transducers and arrays,” IEEE Eng. Med. Biol.15(6), 20–30 (1996). [CrossRef]

IEEE T Signal Process.

• N. Vaswani and W. Lu, “Modified-CS: Modifying compressive sensing for problems with partially known support,” IEEE T Signal Process.58, 4595–4607 (2010).

IEEE Trans. Biomed. Eng.

• D. Han, J. Tian, K. Liu, J. C. Feng, B. Zhang, X. Ma, and C. H. Qin, “Sparsity-promoting tomographic fluorescence imaging with simplified spherical harmonics approximation,” IEEE Trans. Biomed. Eng.57(10), 2564–2567 (2010). [CrossRef] [PubMed]

IEEE Trans. Med. Imaging

• Y. Xu, D. Z. Feng, and L. V. Wang, “Exact frequency-domain reconstruction for thermoacoustic tomography--I: Planar Geometry,” IEEE Trans. Med. Imaging21(7), 823–828 (2002). [CrossRef] [PubMed]
• J. Provost and F. Lesage, “The application of compressed sensing for photo-acoustic tomography,” IEEE Trans. Med. Imaging28(4), 585–594 (2009). [CrossRef] [PubMed]

IJFIPM

• D. Liang, H. F. Zhang, and L. Ying, “Compressed-sensing photoacoustic imaging based on random optical illumination,” IJFIPM2(4), 394–406 (2009). [CrossRef]

J. Biomed. Opt.

• Z. J. Guo, C. H. Li, L. Song, and L. V. Wang, “Compressed sensing in photoacoustic tomography in vivo,” J. Biomed. Opt.15(2), 021311 (2010). [CrossRef] [PubMed]
• C. H. Li, A. Aguirre, J. Gamelin, A. Maurudis, Q. Zhu, and L. V. Wang, “Real-time photoacoustic tomography of cortical hemodynamics in small animals,” J. Biomed. Opt.15(1), 010509 (2010). [CrossRef] [PubMed]
• L. Song, K. Maslov, K. K. Shung, and L. V. Wang, “Ultrasound-array-based real-time photoacoustic microscopy of human pulsatile dynamics in vivo,” J. Biomed. Opt.15(2), 021303 (2010). [CrossRef] [PubMed]
• L. Song, K. Maslov, R. Bitton, K. K. Shung, and L. V. Wang, “Fast 3-D dark-field reflection-mode photoacoustic microscopy in vivo with a 30-MHz ultrasound linear array,” J. Biomed. Opt.13(5), 054028 (2008). [CrossRef] [PubMed]
• W. Wei, X. Li, Q. F. Zhou, K. K. Shung, and Z. Chen, “Integrated ultrasound and photoacoustic probe for co-registered intravascular imaging,” J. Biomed. Opt.16(10), 106001 (2011). [CrossRef] [PubMed]
• S. A. Ermilov, T. Khamapirad, A. Conjusteau, M. H. Leonard, R. Lacewell, K. Mehta, T. Miller, and A. A. Oraevsky, “Laser optoacoustic imaging system for detection of breast cancer,” J. Biomed. Opt.14(2), 024007 (2009). [CrossRef] [PubMed]

Magn. Reson. Med.

• M. Lustig, D. Donoho, and J. M. Pauly, “Sparse MRI: The application of compressed sensing for rapid MR imaging,” Magn. Reson. Med.58(6), 1182–1195 (2007). [CrossRef] [PubMed]
• D. Liang, E. V. R. DiBella, R. R. Chen, and L. Ying, “k-t ISD: Dynamic cardiac MR imaging using compressed sensing with iterative support detection,” Magn. Reson. Med., doi:. [CrossRef]

Med. Phys.

• G. H. Chen, J. Tang, and S. Leng, “Prior image constrained compressed sensing (PICCS): a method to accurately reconstruct dynamic CT images from highly undersampled projection data sets,” Med. Phys.35(2), 660–663 (2008). [CrossRef] [PubMed]

Nat. Biotechnol.

• H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol.24(7), 848–851 (2006). [CrossRef] [PubMed]
• X. D. Wang, Y. J. Pang, G. Ku, X. Y. Xie, G. Stoica, and L. V. Wang, “Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain,” Nat. Biotechnol.21(7), 803–806 (2003). [CrossRef] [PubMed]

Opt. Express

• M. J. Sun, N. Z. Feng, Y. Shen, X. L. Shen, L. Y. Ma, J. G. Li, and Z. H. Wu, “Photoacoustic imaging method based on arc-direction compressed sensing and multi-angle observation,” Opt. Express19(16), 14801–14806 (2011). [CrossRef] [PubMed]

Opt. Lett.

• L. Song, K. Maslov, and L. V. Wang, “Multifocal optical-resolution photoacoustic microscopy in vivo,” Opt. Lett.36(7), 1236–1238 (2011). [CrossRef] [PubMed]
• Z. X. Xie, W. Roberts, P. Carson, X. Liu, C. Tao, and X. Wang, “Evaluation of bladder microvasculature with high-resolution photoacoustic imaging,” Opt. Lett.36(24), 4815–4817 (2011). [CrossRef] [PubMed]

Phys. Rev. E Stat. Nonlin. Soft Matter Phys.

• M. H. Xu and L. V. Wang, “Universal back-projection algorithm for photoacoustic computed tomography,” Phys. Rev. E Stat. Nonlin. Soft Matter Phys.71(1), 016706 (2005). [CrossRef] [PubMed]

Science

• L. V. Wang and S. Hu, “Photoacoustic tomography: in vivo imaging from organelles to organs,” Science335(6075), 1458–1462 (2012). [CrossRef] [PubMed]

SIAM J. Imaging Sciences

• Y. Wang and W. Yin, “Sparse signal reconstruction via iterative support detection,” SIAM J. Imaging Sciences3(3), 462–491 (2010). [CrossRef]

Signal Process.

• L. Jacques, “A short note on compressed sensing with partially known signal support,” Signal Process.90(12), 3308–3312 (2010). [CrossRef]
• Y. Tsaig and D. Donoho, “Extensions of compressed sensing,” Signal Process.86, 549–571 (2006). [CrossRef]

Other

• The Laser Institute of America, American National Standard for Safe Use of Lasers, (ANSI Z136.1–2000), The Laser Institute of America (2000).

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