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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 28 — Dec. 31, 2012
  • pp: 29426–29446

Optics InfoBase > Optics Express > Volume 20 > Issue 28 > Page 29426

Detection and size measurement of individual hemozoin nanocrystals in aquatic environment using a whispering gallery mode resonator

Woosung Kim, Sahin Kaya Ozdemir, Jiangang Zhu, Faraz Monifi, Cevayir Coban, and Lan Yang  »View Author Affiliations


Optics Express, Vol. 20, Issue 28, pp. 29426-29446 (2012)
http://dx.doi.org/10.1364/OE.20.029426


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Abstract

We, for the first time, report the detection and the size measurement of single nanoparticles (i.e. polystyrene) in aquatic environment using mode splitting in a whispering gallery mode (WGM) optical resonator, namely a microtoroid resonator. Using this method we achieved detecting and measuring individual synthetic hemozoin nanocrystals―a hemoglobin degradation by-product of malarial parasites―dispersed in a solution or in air. The results of size measurement in solution and in air agree with each other and with those obtained using scanning electron microscope and dynamic light scattering. Moreover, we compare the sensing capabilities of the degenerate (single resonance) and non-degenerate (split mode, doublet) operation regimes of the WGM resonator.

© 2012 OSA

OCIS Codes
(140.4780) Lasers and laser optics : Optical resonators
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: August 24, 2012
Revised Manuscript: November 9, 2012
Manuscript Accepted: November 11, 2012
Published: December 19, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Woosung Kim, Sahin Kaya Ozdemir, Jiangang Zhu, Faraz Monifi, Cevayir Coban, and Lan Yang, "Detection and size measurement of individual hemozoin nanocrystals in aquatic environment using a whispering gallery mode resonator," Opt. Express 20, 29426-29446 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-28-29426


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