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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 28 — Dec. 31, 2012
  • pp: 29479–29487

Optics InfoBase > Optics Express > Volume 20 > Issue 28 > Page 29479

Thermal stability of biodegradable plasmonic nanoclusters in photoacoustic imaging

Soon Joon Yoon, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov  »View Author Affiliations


Optics Express, Vol. 20, Issue 28, pp. 29479-29487 (2012)
http://dx.doi.org/10.1364/OE.20.029479


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Abstract

The photothermal stability of plasmonic nanoparticles is critically important to perform reliable photoacoustic imaging and photothermal therapy. Recently, biodegradable nanoclusters composed of sub-5 nm primary gold particles and a biodegradable polymer have been reported as clinically-translatable contrast agents for photoacoustic imaging. After cellular internalization, the nanoclusters degrade into 5 nm primary particles for efficient excretion from the body. In this paper, three different sizes of biodegradable nanoclusters were synthesized and the optical properties and photothermal stability of the nanoclusters were investigated and compared to that of gold nanorods. The results of our study indicate that 40 nm and 80 nm biodegradable nanoclusters demonstrate higher photothermal stability compared to gold nanorods. Furthermore, 40 nm nanoclusters produce higher photoacoustic signal than gold nanorods at a given concentration of gold. Therefore, the biodegradable plasmonic nanoclusters can be effectively used for photoacoustic imaging and photothermal therapy.

© 2012 OSA

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 25, 2012
Revised Manuscript: December 2, 2012
Manuscript Accepted: December 9, 2012
Published: December 19, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Soon Joon Yoon, Avinash Murthy, Keith P. Johnston, Konstantin V. Sokolov, and Stanislav Y. Emelianov, "Thermal stability of biodegradable plasmonic nanoclusters in photoacoustic imaging," Opt. Express 20, 29479-29487 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-28-29479


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