Optics InfoBase > Optics Express > Volume 20 > Issue 3 > Page 2220
|
Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrastVivek J. Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, and Alex E. Cable »View Author Affiliations
Vivek J. Srinivasan,1,*
Harsha Radhakrishnan,2
James Y. Jiang,3
Scott Barry,3
and Alex E. Cable3
1MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Charlestown, Massachusetts, 02129, USA 2Center for Neural Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, USA 3Advanced Imaging Group, Thorlabs, Inc., Newton, New Jersey 07860, USA *Corresponding author: vjsriniv@nmr.mgh.harvard.edu |
Optics Express, Vol. 20, Issue 3, pp. 2220-2239 (2012)
http://dx.doi.org/10.1364/OE.20.002220
View Full Text Article
Enhanced HTML 
Acrobat PDF (5232 KB)
Abstract
In vivo optical microscopic imaging techniques have recently emerged as important tools for the study of neurobiological development and pathophysiology. In particular, two-photon microscopy has proved to be a robust and highly flexible method for in vivo imaging in highly scattering tissue. However, two-photon imaging typically requires extrinsic dyes or contrast agents, and imaging depths are limited to a few hundred microns. Here we demonstrate Optical Coherence Microscopy (OCM) for in vivo imaging of neuronal cell bodies and cortical myelination up to depths of ~1.3 mm in the rat neocortex. Imaging does not require the administration of exogenous dyes or contrast agents, and is achieved through intrinsic scattering contrast and image processing alone. Furthermore, using OCM we demonstrate in vivo, quantitative measurements of optical properties (index of refraction and attenuation coefficient) in the cortex, and correlate these properties with laminar cellular architecture determined from the images. Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability.
© 2012 OSA
OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.0180) Medical optics and biotechnology : Microscopy
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5380) Medical optics and biotechnology : Physiology
(170.6900) Medical optics and biotechnology : Three-dimensional microscopy
ToC Category:
Medical Optics and Biotechnology
History
Original Manuscript: November 21, 2011
Revised Manuscript: January 5, 2012
Manuscript Accepted: January 5, 2012
Published: January 17, 2012
Virtual Issues
Vol. 7, Iss. 3 Virtual Journal for Biomedical Optics
Citation
Vivek J. Srinivasan, Harsha Radhakrishnan, James Y. Jiang, Scott Barry, and Alex E. Cable, "Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast," Opt. Express 20, 2220-2239 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-3-2220
Sort: Author | Year | Journal | Reset
References
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
- W. Denk and K. Svoboda, “Photon upmanship: why multiphoton imaging is more than a gimmick,” Neuron18(3), 351–357 (1997).
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
- P. Theer, M. T. Hasan, and W. Denk, “Two-photon imaging to a depth of 1000 μm in living brains by use of a Ti:Al2O3 regenerative amplifier,” Opt. Lett.28(12), 1022–1024 (2003).
- D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, “Deep tissue multiphoton microscopy using longer wavelength excitation,” Opt. Express17(16), 13354–13364 (2009).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
- J. Binding, J. Ben Arous, J. F. Léger, S. Gigan, C. Boccara, and L. Bourdieu, “Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy,” Opt. Express19(6), 4833–4847 (2011).
- M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004).
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
- K. F. Palmer and D. Williams, “Optical-properties of water in near-infrared,” J. Opt. Soc. Am.64(8), 1107–1110 (1974).
- D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express12(19), 4353–4365 (2004).
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
- V. J. Srinivasan, J. Y. Jiang, M. A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A. E. Cable, and D. A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett.35(1), 43–45 (2010).
- W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett.24(17), 1221–1223 (1999).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009).
- R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express15(7), 4083–4097 (2007).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008).
- N. R. Kreisman and J. C. LaManna, “Rapid and slow swelling during hypoxia in the CA1 region of rat hippocampal slices,” J. Neurophysiol.82(1), 320–329 (1999).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- M. Müller and G. G. Somjen, “Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization,” J. Neurophysiol.82(4), 1818–1831 (1999).
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
- D. S. Tuch, “Q-ball imaging,” Magn. Reson. Med.52(6), 1358–1372 (2004).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
Aalders, M. C. G.
Abosch, A.
Aitken, P. G.
Akkin, T.
Al-Qaisi, M. K.
Andrew, R. D.
Asgari, H. S.
Backman, V.
Badizadegan, K.
Barry, S.
Bartlett, L. A.
Basser, P. J.
Beaurepaire, E.
Ben Arous, J.
Binding, J.
Black, A. J.
Blonder, G. E.
Boas, D. A.
Boccara, C.
Boppart, S. A.
Bouma, B. E.
Bourdieu, L.
Brezinski, M. E.
Burgess, R. W.
Burns, L. D.
Cable, A. E.
Campagnola, P.
Chaigneau, E.
Charpak, S.
Chia, T. H.
Chileuitt, L.
Choi, W.
Clascá, F.
Cohen, Y.
Crawford, J. M.
Dasari, R. R.
Denk, W.
Drexler, W.
Duker, J. S.
Durst, M. E.
Enright, L. E.
Faber, D. J.
Fang-Yen, C.
Fayuk, D.
Feld, M. S.
Foster, T. H.
Fujimoto, J. G.
Fukumura, D.
Galazo, M. J.
Gelbard, H. A.
Ghosh, K. K.
Gigan, S.
Gorczynska, I.
Goto, T.
Gruber, A.
Hagmann, P.
Hamano, T.
Hansen, A. J.
Hanson, S. R.
Hasan, M. T.
Hatanaka, R.
Hee, M. R.
Helmchen, F.
Hoehn-Berlage, M.
Hossmann, K. A.
Hrabetová, S.
Hurst, S.
Ippen, E. P.
Itzkan, I.
Izatt, J. A.
Jacques, S. L.
Jain, R. K.
Jarvis, C. R.
Jiang, J. Y.
Kärtner, F. X.
Kasischke, K. A.
Kawashima, R.
Kerr, J. N.
Kirchhoff, F.
Kleinfeld, D.
Ko, T. H.
Kobat, D.
Kohno, K.
Kowalczyk, A.
Kreisman, N. R.
Kucharczyk, J.
LaManna, J. C.
Lambert, E. M.
Lanning, R. M.
LaPorta, A.
LeBihan, D.
Léger, J. F.
Leibfritz, D.
Levene, M. J.
Li, X. D.
Lima, C.
Lou, N.
Lovatt, D.
Lue, N.
Ma, Z.
Manoharan, R.
Masri, D.
Mattiello, J.
Mertz, J.
Mies, G.
Mintorovitch, J.
Morgner, U.
Moseley, M. E.
Mukamel, E. A.
Müller, M.
Munn, L. L.
Murphy, T. H.
Nedergaard, M.
Netoff, T. I.
Nicholson, C.
Nimmerjahn, A.
Nishimura, N.
Norman, D.
Norris, D. G.
Nusrat, A.
Obeidat, A. S.
Ogawa, T.
Oh, S.
Oheim, M.
Owen, G. M.
Padera, T. P.
Palmer, K. F.
Panepento, B.
Peng, W.
Perelman, L. T.
Pérez-de-Manzo, F.
Pitris, C.
Polischuk, T. M.
Porrero, C.
Raccuia-Behling, F.
Radhakrishnan, H.
Reese, T. G.
Riera, J.
Rubio-Garrido, P.
Ruvinskaya, S.
Sakadzic, S.
Samatham, R.
Schaffer, C. B.
Schnitzer, M. J.
Seiler, M.
Shields, S.
Shimizu, H.
Slusher, R. E.
Somjen, G. G.
Southern, J. F.
Srinivasan, V. J.
Stepnoski, R. A.
Stigen, T. W.
Strickler, J. H.
Stylianopoulos, T.
Sumiyoshi, A.
Sun, A.
Svoboda, K.
Swanson, E. A.
Takano, T.
Tao, L.
Tearney, G. J.
Theer, P.
Tian, G. F.
Tseng, W. Y. I.
Tsuruda, J.
Tuch, D. S.
Turner, D. A.
Tyrrell, J. A.
Vakoc, B. J.
Van Dam, J.
van der Meer, F. J.
van Leeuwen, T.
Wallace, M.
Wang, H.
Wang, R. K.
Webb, W. W.
Wedeen, V. J.
Wei Ho, E. T.
Weinstein, P. R.
Weisskoff, R. M.
Wendland, M. F.
Williams, D.
Wilt, B. A.
Wojtkowski, M.
Wong, A. W.
Wu, W.
Xu, C.
Yaseen, M. A.
Zhang, S.
Zhu, J. F.
Zonios, G.
Abosch, A.
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
Bartlett, L. A.
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
Binding, J.
Black, A. J.
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- V. J. Srinivasan, J. Y. Jiang, M. A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A. E. Cable, and D. A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett.35(1), 43–45 (2010).
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
Boppart, S. A.
Bouma, B. E.
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
Brezinski, M. E.
Burgess, R. W.
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
Campagnola, P.
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- P. Theer, M. T. Hasan, and W. Denk, “Two-photon imaging to a depth of 1000 μm in living brains by use of a Ti:Al2O3 regenerative amplifier,” Opt. Lett.28(12), 1022–1024 (2003).
- W. Denk and K. Svoboda, “Photon upmanship: why multiphoton imaging is more than a gimmick,” Neuron18(3), 351–357 (1997).
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
- W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008).
- W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett.24(17), 1221–1223 (1999).
Durst, M. E.
Enright, L. E.
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
Fang-Yen, C.
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
- W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008).
- M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004).
- W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett.24(17), 1221–1223 (1999).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
- J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
Gorczynska, I.
Goto, T.
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
Hagmann, P.
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
Hasan, M. T.
Hatanaka, R.
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
- J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
Ippen, E. P.
Itzkan, I.
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
Jacques, S. L.
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
- R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express15(7), 4083–4097 (2007).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
Kärtner, F. X.
Kasischke, K. A.
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
Kobat, D.
Kohno, K.
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
Kreisman, N. R.
- N. R. Kreisman and J. C. LaManna, “Rapid and slow swelling during hypoxia in the CA1 region of rat hippocampal slices,” J. Neurophysiol.82(1), 320–329 (1999).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- N. R. Kreisman and J. C. LaManna, “Rapid and slow swelling during hypoxia in the CA1 region of rat hippocampal slices,” J. Neurophysiol.82(1), 320–329 (1999).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
Leibfritz, D.
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009).
Lima, C.
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
Manoharan, R.
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
Moseley, M. E.
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
- M. Müller and G. G. Somjen, “Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization,” J. Neurophysiol.82(4), 1818–1831 (1999).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
Norman, D.
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
Padera, T. P.
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
Panepento, B.
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
Polischuk, T. M.
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
Reese, T. G.
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
Sakadzic, S.
Samatham, R.
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
Schnitzer, M. J.
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- M. Müller and G. G. Somjen, “Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization,” J. Neurophysiol.82(4), 1818–1831 (1999).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
Srinivasan, V. J.
- V. J. Srinivasan, J. Y. Jiang, M. A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A. E. Cable, and D. A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett.35(1), 43–45 (2010).
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
- M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004).
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- W. Denk and K. Svoboda, “Photon upmanship: why multiphoton imaging is more than a gimmick,” Neuron18(3), 351–357 (1997).
Takano, T.
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
Tian, G. F.
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- D. S. Tuch, “Q-ball imaging,” Magn. Reson. Med.52(6), 1358–1372 (2004).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
van Leeuwen, T.
Wallace, M.
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
Webb, W. W.
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
Wilt, B. A.
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
Wong, A. W.
Wu, W.
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
- V. J. Srinivasan, J. Y. Jiang, M. A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A. E. Cable, and D. A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett.35(1), 43–45 (2010).
Yaseen, M. A.
Zhang, S.
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
Annu. Rev. Neurosci.
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
Biophys. J.
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
Brain Res.
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
Cereb. Cortex
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
J. Biomed. Opt.
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
J. Cereb. Blood Flow Metab.
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
J. Neurophysiol.
- M. Müller and G. G. Somjen, “Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization,” J. Neurophysiol.82(4), 1818–1831 (1999).
- T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009).
- N. R. Kreisman and J. C. LaManna, “Rapid and slow swelling during hypoxia in the CA1 region of rat hippocampal slices,” J. Neurophysiol.82(1), 320–329 (1999).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
J. Neurosci. Methods
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
J. Opt. Soc. Am.
Magn. Reson. Med.
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
- D. S. Tuch, “Q-ball imaging,” Magn. Reson. Med.52(6), 1358–1372 (2004).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
Methods
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
Nat. Med.
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
Nat. Methods
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
Nat. Neurosci.
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
Neurobiol. Dis.
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
Neuroimage
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
Neuron
- W. Denk and K. Svoboda, “Photon upmanship: why multiphoton imaging is more than a gimmick,” Neuron18(3), 351–357 (1997).
Opt. Commun.
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
Opt. Express
- J. Binding, J. Ben Arous, J. F. Léger, S. Gigan, C. Boccara, and L. Bourdieu, “Brain refractive index measured in vivo with high-NA defocus-corrected full-field OCT and consequences for two-photon microscopy,” Opt. Express19(6), 4833–4847 (2011).
- M. Wojtkowski, V. J. Srinivasan, T. H. Ko, J. G. Fujimoto, A. Kowalczyk, and J. S. Duker, “Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation,” Opt. Express12(11), 2404–2422 (2004).
- V. J. Srinivasan, S. Sakadzić, I. Gorczynska, S. Ruvinskaya, W. Wu, J. G. Fujimoto, and D. A. Boas, “Quantitative cerebral blood flow with optical coherence tomography,” Opt. Express18(3), 2477–2494 (2010).
- D. J. Faber, F. J. van der Meer, M. C. G. Aalders, and T. van Leeuwen, “Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography,” Opt. Express12(19), 4353–4365 (2004).
- D. Kobat, M. E. Durst, N. Nishimura, A. W. Wong, C. B. Schaffer, and C. Xu, “Deep tissue multiphoton microscopy using longer wavelength excitation,” Opt. Express17(16), 13354–13364 (2009).
- R. K. Wang, S. L. Jacques, Z. Ma, S. Hurst, S. R. Hanson, and A. Gruber, “Three dimensional optical angiography,” Opt. Express15(7), 4083–4097 (2007).
Opt. Lett.
- V. J. Srinivasan, J. Y. Jiang, M. A. Yaseen, H. Radhakrishnan, W. Wu, S. Barry, A. E. Cable, and D. A. Boas, “Rapid volumetric angiography of cortical microvasculature with optical coherence tomography,” Opt. Lett.35(1), 43–45 (2010).
- W. Drexler, U. Morgner, F. X. Kärtner, C. Pitris, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, “In vivo ultrahigh-resolution optical coherence tomography,” Opt. Lett.24(17), 1221–1223 (1999).
- J. A. Izatt, M. R. Hee, G. M. Owen, E. A. Swanson, and J. G. Fujimoto, “Optical coherence microscopy in scattering media,” Opt. Lett.19(8), 590–592 (1994).
- G. J. Tearney, M. E. Brezinski, J. F. Southern, B. E. Bouma, M. R. Hee, and J. G. Fujimoto, “Determination of the refractive index of highly scattering human tissue by optical coherence tomography,” Opt. Lett.20(21), 2258 (1995).
- P. Theer, M. T. Hasan, and W. Denk, “Two-photon imaging to a depth of 1000 μm in living brains by use of a Ti:Al2O3 regenerative amplifier,” Opt. Lett.28(12), 1022–1024 (2003).
Phys. Rev. Lett.
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
Proc. Natl. Acad. Sci. U.S.A.
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
Prog. Retin. Eye Res.
- W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008).
Radiology
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
Science
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
2011, Binding, Opt. Express
2011, Kasischke, J. Cereb. Blood Flow Metab.
- K. A. Kasischke, E. M. Lambert, B. Panepento, A. Sun, H. A. Gelbard, R. W. Burgess, T. H. Foster, and M. Nedergaard, “Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions,” J. Cereb. Blood Flow Metab.31(1), 68–81 (2011).
- H. Wang, A. J. Black, J. F. Zhu, T. W. Stigen, M. K. Al-Qaisi, T. I. Netoff, A. Abosch, and T. Akkin, “Reconstructing micrometer-scale fiber pathways in the brain: multi-contrast optical coherence tomography based tractography,” Neuroimage58(4), 984–992 (2011).
- T. Goto, R. Hatanaka, T. Ogawa, A. Sumiyoshi, J. Riera, and R. Kawashima, “An evaluation of the conductivity profile in the somatosensory barrel cortex of Wistar rats,” J. Neurophysiol.104(6), 3388–3412 (2010).
2010, Srinivasan, Opt. Lett.
2009, Wilt, Annu. Rev. Neurosci.
- B. A. Wilt, L. D. Burns, E. T. Wei Ho, K. K. Ghosh, E. A. Mukamel, and M. J. Schnitzer, “Advances in light microscopy for neuroscience,” Annu. Rev. Neurosci.32(1), 435–506 (2009).
2009, Rubio-Garrido, Cereb. Cortex
- P. Rubio-Garrido, F. Pérez-de-Manzo, C. Porrero, M. J. Galazo, and F. Clascá, “Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent,” Cereb. Cortex19(10), 2380–2395 (2009).
- T. H. Chia and M. J. Levene, “Microprisms for in vivo multilayer cortical imaging,” J. Neurophysiol.102(2), 1310–1314 (2009).
- B. J. Vakoc, R. M. Lanning, J. A. Tyrrell, T. P. Padera, L. A. Bartlett, T. Stylianopoulos, L. L. Munn, G. J. Tearney, D. Fukumura, R. K. Jain, and B. E. Bouma, “Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging,” Nat. Med.15(10), 1219–1223 (2009).
- W. Drexler and J. G. Fujimoto, “State-of-the-art retinal optical coherence tomography,” Prog. Retin. Eye Res.27(1), 45–88 (2008).
- R. Samatham, S. L. Jacques, and P. Campagnola, “Optical properties of mutant versus wild-type mouse skin measured by reflectance-mode confocal scanning laser microscopy (rCSLM),” J. Biomed. Opt.13(4), 041309 (2008).
2007, Enright, J. Cereb. Blood Flow Metab.
- L. E. Enright, S. Zhang, and T. H. Murphy, “Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo,” J. Cereb. Blood Flow Metab.27(6), 1185–1200 (2007).
- T. Takano, G. F. Tian, W. Peng, N. Lou, D. Lovatt, A. J. Hansen, K. A. Kasischke, and M. Nedergaard, “Cortical spreading depression causes and coincides with tissue hypoxia,” Nat. Neurosci.10(6), 754–762 (2007).
- W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, “Tomographic phase microscopy,” Nat. Methods4(9), 717–719 (2007).
- V. J. Wedeen, P. Hagmann, W. Y. I. Tseng, T. G. Reese, and R. M. Weisskoff, “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging,” Magn. Reson. Med.54(6), 1377–1386 (2005).
- D. S. Tuch, “Q-ball imaging,” Magn. Reson. Med.52(6), 1358–1372 (2004).
2004, Wojtkowski, Opt. Express
2004, Nimmerjahn, Nat. Methods
- A. Nimmerjahn, F. Kirchhoff, J. N. Kerr, and F. Helmchen, “Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo,” Nat. Methods1(1), 31–37 (2004).
2002, Tao, Brain Res.
- L. Tao, D. Masri, S. Hrabetová, and C. Nicholson, “Light scattering in rat neocortical slices differs during spreading depression and ischemia,” Brain Res.952(2), 290–300 (2002).
- M. Oheim, E. Beaurepaire, E. Chaigneau, J. Mertz, and S. Charpak, “Two-photon microscopy in brain tissue: parameters influencing the imaging depth,” J. Neurosci. Methods111(1), 29–37 (2001).
- E. Beaurepaire, M. Oheim, and J. Mertz, “Ultra-deep two-photon fluorescence excitation in turbid media,” Opt. Commun.188(1-4), 25–29 (2001).
1999, Kreisman, J. Neurophysiol.
- N. R. Kreisman and J. C. LaManna, “Rapid and slow swelling during hypoxia in the CA1 region of rat hippocampal slices,” J. Neurophysiol.82(1), 320–329 (1999).
- P. G. Aitken, D. Fayuk, G. G. Somjen, and D. A. Turner, “Use of intrinsic optical signals to monitor physiological changes in brain tissue slices,” Methods18(2), 91–103 (1999).
- M. Müller and G. G. Somjen, “Intrinsic optical signals in rat hippocampal slices during hypoxia-induced spreading depression-like depolarization,” J. Neurophysiol.82(4), 1818–1831 (1999).
- R. D. Andrew, C. R. Jarvis, and A. S. Obeidat, “Potential sources of intrinsic optical signals imaged in live brain slices,” Methods18(2), 185–196, 179 (1999).
- T. M. Polischuk, C. R. Jarvis, and R. D. Andrew, “Intrinsic optical signaling denoting neuronal damage in response to acute excitotoxic insult by domoic acid in the hippocampal slice,” Neurobiol. Dis.4(6), 423–437 (1998).
- L. T. Perelman, V. Backman, M. Wallace, G. Zonios, R. Manoharan, A. Nusrat, S. Shields, M. Seiler, C. Lima, T. Hamano, I. Itzkan, J. Van Dam, J. M. Crawford, and M. S. Feld, “Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution,” Phys. Rev. Lett.80(3), 627–630 (1998).
- W. Denk and K. Svoboda, “Photon upmanship: why multiphoton imaging is more than a gimmick,” Neuron18(3), 351–357 (1997).
1995, Hoehn-Berlage, J. Cereb. Blood Flow Metab.
- M. Hoehn-Berlage, D. G. Norris, K. Kohno, G. Mies, D. Leibfritz, and K. A. Hossmann, “Evolution of regional changes in apparent diffusion coefficient during focal ischemia of rat brain: the relationship of quantitative diffusion NMR imaging to reduction in cerebral blood flow and metabolic disturbances,” J. Cereb. Blood Flow Metab.15(6), 1002–1011 (1995).
- P. J. Basser, J. Mattiello, and D. LeBihan, “MR diffusion tensor spectroscopy and imaging,” Biophys. J.66(1), 259–267 (1994).
1991, Stepnoski, Proc. Natl. Acad. Sci. U.S.A.
- R. A. Stepnoski, A. LaPorta, F. Raccuia-Behling, G. E. Blonder, R. E. Slusher, and D. Kleinfeld, “Noninvasive detection of changes in membrane potential in cultured neurons by light scattering,” Proc. Natl. Acad. Sci. U.S.A.88(21), 9382–9386 (1991).
- W. Denk, J. H. Strickler, and W. W. Webb, “Two-photon laser scanning fluorescence microscopy,” Science248(4951), 73–76 (1990).
- M. E. Moseley, Y. Cohen, J. Kucharczyk, J. Mintorovitch, H. S. Asgari, M. F. Wendland, J. Tsuruda, and D. Norman, “Diffusion-weighted MR imaging of anisotropic water diffusion in cat central nervous system,” Radiology176(2), 439–445 (1990).
- M. E. Moseley, Y. Cohen, J. Mintorovitch, L. Chileuitt, H. Shimizu, J. Kucharczyk, M. F. Wendland, and P. R. Weinstein, “Early detection of regional cerebral-ischemia in cats - comparison of diffusion-weighted and T2-weighted MRI and spectroscopy,” Magn. Reson. Med.14(2), 330–346 (1990).
Cited By |
 Alert me when this paper is cited |
OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.
Multimedia
| Multimedia Files | Recommended Software |
| » Media 1: AVI (5450 KB) | QuickTime |
| » Media 2: AVI (17154 KB) | QuickTime |
| » Media 3: AVI (5934 KB) | QuickTime |
| » Media 4: AVI (2686 KB) | QuickTime |
| » Media 5: AVI (1909 KB) | QuickTime |
Related Journal Articles 
- Thermal-light full-field optical coherence tomography (OL)
- Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography (OL)
- Rapid volumetric angiography of cortical microvasculature with optical coherence tomography (OL)
- Quantitative cerebral blood flow with Optical Coherence Tomography (OE)
- OCT methods for capillary velocimetry (BOE)
Related Conference Papers
- Pump-Probe Scheme for Optical Coherence Tomography Using Indocyanine Green Mixed with Albumin or Human Plasma
- Two-photon microscopy reveals that cortical blood flow reverses direction at the first branch that lies downstream from a localized photothrombotic clot
- Compact ultrahigh resolution OCT system for real-time in vivo imaging
- Non-linear interferometric vibrational imaging
- High flow velocity imaging using color Doppler optical coherence tomography
« Previous Article | Next Article »
OSA is a member of 
For optimal display we recommend the following web browsers:
- Firefox 11+
- Google Chrome 17+
- Internet Explorer 9+
- Safari 5+