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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 7 — Mar. 26, 2012
  • pp: 7195–7205

All-optical phase modulation for integrated interferometric biosensors

Stefania Dante, Daphné Duval, Borja Sepúlveda, Ana Belen González-Guerrero, José Ramón Sendra, and Laura M. Lechuga  »View Author Affiliations


Optics Express, Vol. 20, Issue 7, pp. 7195-7205 (2012)
http://dx.doi.org/10.1364/OE.20.007195


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Abstract

We present the theoretical and the experimental implementation of an all-optical phase modulation system in integrated Mach-Zehnder Interferometers to solve the drawbacks related to the periodic nature of the interferometric signal. Sensor phase is tuned by modulating the emission wavelength of low-cost commercial laser diodes by changing their output power. FFT deconvolution of the signal allows for direct phase readout, immune to sensitivity variations and to light intensity fluctuations. This simple phase modulation scheme increases the signal-to-noise ratio of the measurements in one order of magnitude, rendering in a sensor with a detection limit of 1.9·10−7 RIU. The viability of the all-optical modulation approach is demonstrated with an immunoassay detection as a biosensing proof of concept.

© 2012 OSA

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.5060) Instrumentation, measurement, and metrology : Phase modulation
(130.3120) Integrated optics : Integrated optics devices
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: December 5, 2011
Revised Manuscript: February 3, 2012
Manuscript Accepted: February 6, 2012
Published: March 14, 2012

Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Stefania Dante, Daphné Duval, Borja Sepúlveda, Ana Belen González-Guerrero, José Ramón Sendra, and Laura M. Lechuga, "All-optical phase modulation for integrated interferometric biosensors," Opt. Express 20, 7195-7205 (2012)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-20-7-7195


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References

  1. X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, and Y. J. Sun, “Sensitive optical biosensors for unlabeled targets: a review,” Anal. Chim. Acta620(1-2), 8–26 (2008). [CrossRef] [PubMed]
  2. M. C. Estevez, M. Álvarez, and L. M. Lechuga, “Integrated Optical devices for lab-on-a-chip biosensing applications,” Laser Photon. Rev. DOI: (2011). [CrossRef]
  3. A. Ymeti, J. S. Kanger, R. Wijn, P. V. Lambeck, and J. Greve, “Development of a multichannel integrated interferometer immunosensor,” Sens. Actuators B Chem.83(1-3), 1–7 (2002). [CrossRef]
  4. K. Schmitt, B. Schirmer, C. Hoffmann, A. Brandenburg, and P. Meyrueis, “Interferometric biosensor based on planar optical waveguide sensor chips for label-free detection of surface bound bioreactions,” Biosens. Bioelectron.22(11), 2591–2597 (2007). [CrossRef] [PubMed]
  5. G. Heideman and P. V. Lambeck, “Remote opto-chemical sensing with extreme sensitivity: design, fabrication and performance of a pigtailed integrated optical phase-modulated Mach–Zehnder interferometer system,” Sens. Actuators B Chem.61(1-3), 100–127 (1999). [CrossRef]
  6. B. Sepúlveda, J. Sánchez del Río, M. Moreno, F. J. Blanco, K. Mayora, C. Domínguez, and L. M. Lechuga, “Optical biosensor micro-systems based on the integration of highly sensitive Mach-Zehnder interferometer devices,” J. Opt. A, Pure Appl. Opt.8(7), S561–S566 (2006). [CrossRef]
  7. B. H. Schneider, E. L. Dickinson, M. D. Vach, J. V. Hoijer, and L. V. Howard, “Optical chip immunoassay for hCG in human whole blood,” Biosens. Bioelectron.15(11-12), 597–604 (2000). [CrossRef] [PubMed]
  8. D. J. Bornhop, J. C. Latham, A. Kussrow, D. A. Markov, R. D. Jones, and H. S. Sørensen, “Free-solution, label-free molecular interactions studied by back-scattering interferometry,” Science317(5845), 1732–1736 (2007). [CrossRef] [PubMed]
  9. K. E. Zinoviev, A. B. González-Guerrero, C. Domínguez, and L. M. Lechuga, “Integrated Bimodal Waveguide Interferometric Biosensor for Label-free Analysis,” J. Lightwave Technol.29(13), 1926–1930 (2011). [CrossRef]
  10. B. Sepúlveda, G. Armelles, and L. M. Lechuga, “Magneto-optical phase modulation in integrated Mach–Zehnder interferometric sensors,” Sens. Actuators A Phys.134(2), 339–347 (2007). [CrossRef]
  11. K. Preston, S. Manipatruni, A. Gondarenko, C. B. Poitras, and M. Lipson, “Deposited silicon high-speed integrated electro-optic modulator,” Opt. Express17(7), 5118–5124 (2009). [CrossRef] [PubMed]
  12. M. B. Dühring and O. Sigmund, “Improving the acousto-optical interaction in a Mach-Zehnder interferometer,” J. Appl. Phys.105(8), 083529 (2009). [CrossRef]
  13. P. Dumais, C. L. Callender, J. P. Noad, and C. J. Ledderhof, “Integrated optical sensor using a liquid-core waveguide in a Mach-Zehnder interferometer,” Opt. Express16(22), 18164–18172 (2008). [CrossRef] [PubMed]
  14. V. Passaro, F. Magno, and A. Tsarev, “Investigation of thermo-optic effect and multi-reflector tunable filter/multiplexer in SOI waveguides,” Opt. Express13(9), 3429–3437 (2005). [CrossRef] [PubMed]
  15. A. Dér, S. Valkai, A. Mathesz, I. Andó, E. K. Wolff, and P. Ormos, “Protein-based all-optical sensor device,” Sens. Actuators B Chem.151(1), 26–29 (2010). [CrossRef]
  16. A. Dandridge and A. B. Tveten, “Phase compensation in interferometric fiber-optic sensors,” Opt. Lett.7(6), 279–281 (1982). [CrossRef] [PubMed]
  17. U. Minoni, E. Sardini, E. Gelmini, F. Docchio, and D. Marioli, “A high-frequency sinusoidal phase-modulation interferometer using an electro-optic modulator: Development and evaluation,” Rev. Sci. Instrum.62(11), 2579–2583 (1991). [CrossRef]
  18. D. Guo, M. Wang, and S. Tan, “Self-mixing interferometer based on sinusoidal phase modulating technique,” Opt. Express13(5), 1537–1543 (2005). [CrossRef] [PubMed]
  19. F. Prieto, B. Sepúlveda, A. Calle, A. Llobera, C. Domínguez, A. Abad, A. Montoya, and L. M. Lechuga, “An integrated optical interferometric nanodevice based on silicon technology for biosensor applications,” Nanotechnology14(8), 907–912 (2003). [CrossRef]
  20. K. Zinoviev, L. G. Carrascosa, J. Sánchez del Río, B. Sepúlveda, C. Domínguez, and L. M. Lechuga, “Silicon Photonic Biosensors for Lab-on-a-Chip Applications,” Adv. Opt. Technol.2008, 383927 (2008). [CrossRef]
  21. T. Gao and L. J. Rothberg, “Label-free sensing of binding to microarrays using Brewster angle straddle interferometry,” Anal. Chem.79(20), 7589–7595 (2007). [CrossRef] [PubMed]
  22. Y. Chen, P. Xu, M. Liu, and X. Li, “Bio/chemical detection in liquid with self-sensing Pr-Oxi-Lever (piezo-resistive SiO2 cantilever) sensors,” Microelectron. Eng.87(12), 2468–2474 (2010). [CrossRef]

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