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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 20, Iss. 9 — Apr. 23, 2012
  • pp: 9911–9918

Quantitative phase contrast optimised cancerous cell differentiation via ptychography

Daniel Claus, Andrew M. Maiden, Fucai Zhang, Francis G. R. Sweeney, Martin J. Humphry, Hermann Schluesener, and John M. Rodenburg  »View Author Affiliations

Optics Express, Vol. 20, Issue 9, pp. 9911-9918 (2012)

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This paper shows that visible-light ptychography can be used to distinguish quantitatively between healthy and tumorous unstained cells. Advantages of ptychography in comparison to conventional phase-sensitive imaging techniques are highlighted. A novel procedure to automatically refocus ptychographic reconstructions is also presented, which improves quantitative analysis.

© 2012 OSA

OCIS Codes
(070.0070) Fourier optics and signal processing : Fourier optics and signal processing
(100.5070) Image processing : Phase retrieval
(110.0180) Imaging systems : Microscopy
(120.5050) Instrumentation, measurement, and metrology : Phase measurement
(170.3880) Medical optics and biotechnology : Medical and biological imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: January 5, 2012
Revised Manuscript: February 22, 2012
Manuscript Accepted: February 23, 2012
Published: April 16, 2012

Virtual Issues
Vol. 7, Iss. 6 Virtual Journal for Biomedical Optics

Daniel Claus, Andrew M. Maiden, Fucai Zhang, Francis G. R. Sweeney, Martin J. Humphry, Hermann Schluesener, and John M. Rodenburg, "Quantitative phase contrast optimised cancerous cell differentiation via ptychography," Opt. Express 20, 9911-9918 (2012)

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