Microring resonators with flow-through nanopores for nanoparticle counting and sizing

doi:10.1364/OE.21.000229

Microring resonators with flow-through nanopores for nanoparticle counting and sizing

Yubo Li and Xudong Fan »View Author Affiliations

Optics Express, Vol. 21, Issue 1, pp. 229-237 (2013)
http://dx.doi.org/10.1364/OE.21.000229

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Abstract
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Abstract

This paper proposes a high precision method for nanoparticle counting and sizing using a microring resonator-waveguide system that contains a flow-through nanopore. Theoretical analysis is carried out based on the coupled-mode theory, showing that when the nanoparticle passes the nanopore a temporal pulse signal can be detected and that the peak amplitude depends linearly on the nanoparticle volume. It is estimated that a nanoparticle of sub-10 nm in size may be detectable.

OCIS Codes
(120.1880) Instrumentation, measurement, and metrology : Detection
(230.3990) Optical devices : Micro-optical devices
(230.5750) Optical devices : Resonators
(280.1415) Remote sensing and sensors : Biological sensing and sensors

ToC Category:
Sensors

History
Original Manuscript: October 10, 2012
Revised Manuscript: November 30, 2012
Manuscript Accepted: December 20, 2012
Published: January 3, 2013

Virtual Issues
Vol. 8, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Yubo Li and Xudong Fan, "Microring resonators with flow-through nanopores for nanoparticle counting and sizing," Opt. Express 21, 229-237 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-1-229

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References

G. S. Roberts, D. Kozak, W. Anderson, M. F. Broom, R. Vogel, and M. Trau, “Tunable nano/micropores for particle detection and discrimination: Scanning ion occlusion spectroscopy,” Small6(23), 2653–2658 (2010). [CrossRef] [PubMed]
R. Vogel, G. Willmott, D. Kozak, G. S. Roberts, W. Anderson, L. Groenewegen, B. Glossop, A. Barnett, A. Turner, and M. Trau, “Quantitative sizing of nano/microparticles with a tunable elastomeric pore sensor,” Anal. Chem.83(9), 3499–3506 (2011). [CrossRef] [PubMed]
F. Vollmer, S. Arnold, and D. Keng, “Single virus detection from the reactive shift of a whispering-gallery mode,” Proc. Natl. Acad. Sci. U.S.A.105(52), 20701–20704 (2008). [CrossRef] [PubMed]
H. Zhu, I. M. White, J. D. Suter, M. Zourob, and X. Fan, “Opto-fluidic micro-ring resonator for sensitive label-free viral detection,” Analyst (Lond.)133(3), 356–360 (2008). [CrossRef] [PubMed]
B. Koch, Y. Yi, J.-Y. Zhang, S. Znameroski, and T. Smith, “Reflection-mode sensing using optical microresonators,” Appl. Phys. Lett.95(20), 201111 (2009). [CrossRef]
B. Koch, L. Carson, C.-M. Guo, C.-Y. Lee, Y. Yi, J.-Y. Zhang, M. Zin, S. Znameroski, and T. Smith, “Hurricane: A simplified optical resonator for optical-power-based sensing with nano-particle taggants,” Sens. Actuators B Chem.147(2), 573–580 (2010).
S. Wang, K. Broderick, H. Smith, and Y. Yi, “Strong coupling between on chip notched ring resonator and nanoparticle,” Appl. Phys. Lett.97(5), 051102 (2010). [CrossRef]
A. Haddadpour and Y. Yi, “Metallic nanoparticle on micro ring resonator for bio optical detection and sensing,” Biomed. Opt. Express1(2), 378–384 (2010). [CrossRef] [PubMed]
J. Zhu, S. K. Ozdemir, Y.-F. Xiao, L. Li, L. He, D.-R. Chen, and L. Yang, “On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator,” Nat. Photonics4(1), 46–49 (2010). [CrossRef]
S. I. Shopova, R. Rajmangal, Y. Nishida, and S. Arnold, “Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser,” Rev. Sci. Instrum.81(10), 103110 (2010). [CrossRef] [PubMed]
T. Lu, H. Lee, T. Chen, S. Herchak, J.-H. Kim, S. E. Fraser, R. C. Flagan, and K. Vahala, “High sensitivity nanoparticle detection using optical microcavities,” Proc. Natl. Acad. Sci. U.S.A.108(15), 5976–5979 (2011). [CrossRef] [PubMed]
J. Zhu, Ş. K. Özdemir, L. He, D.-R. Chen, and L. Yang, “Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities,” Opt. Express19(17), 16195–16206 (2011). [CrossRef] [PubMed]
L. He, Ş. K. Özdemir, J. Zhu, W. Kim, and L. Yang, “Detecting single viruses and nanoparticles usingwhispering gallery microlasers,” Nat. Nanotechnol.6(7), 428 (2011). [CrossRef]
V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, and S. Arnold, “Taking whispering gallery-mode single virus detection and sizing to the limit,” Appl. Phys. Lett.101(4), 043704 (2012). [CrossRef]
B. E. Little, J.-P. Laine, and H. A. Haus, “Analytic theory of coupling from tapered fibers and half-blocks into microsphere resonators,” J. Lightwave Technol.17(4), 704–715 (1999). [CrossRef]
I. M. White, H. Oveys, X. Fan, T. L. Smith, and J. Zhang, “Integrated multiplexed biosensors based on liquid core optical ring resonators and antiresonant reflecting optical waveguides,” Appl. Phys. Lett.89(19), 191106 (2006). [CrossRef]
K. Okamoto, Fundamentals of Optical Waveguides (Academic Press, 2000).
H. Li, L. Shang, X. Tu, L. Liu, and L. Xu, “Coupling variation induced ultrasensitive label-free biosensing by using single mode coupled microcavity laser,” J. Am. Chem. Soc.131(46), 16612–16613 (2009). [CrossRef] [PubMed]
Y. Guo, J. Y. Ye, C. Divin, B. Huang, T. P. Thomas, J. R. Baker, and T. B. Norris, “Real-time biomolecular binding detection using a sensitive photonic crystal biosensor,” Anal. Chem.82(12), 5211–5218 (2010). [CrossRef] [PubMed]

Anderson, W.
Arnold, S.
Baker, J. R.
Barnett, A.
Broderick, K.
Broom, M. F.
Carson, L.
Chen, D.-R.
Chen, T.
Dantham, V. R.
Divin, C.
Fan, X.
Flagan, R. C.
Fraser, S. E.
Glossop, B.
Groenewegen, L.
Guo, C.-M.
Guo, Y.
Haddadpour, A.
Haus, H. A.
He, L.
Herchak, S.
Holler, S.
Huang, B.
Keng, D.
Kim, J.-H.
Kim, W.
Koch, B.
Kolchenko, V.
Kozak, D.
Laine, J.-P.
Lee, C.-Y.
Lee, H.
Li, H.
Li, L.
Little, B. E.
Liu, L.
Lu, T.
Nishida, Y.
Norris, T. B.
Oveys, H.
Ozdemir, S. K.
Özdemir, S. K.
Rajmangal, R.
Roberts, G. S.
Shang, L.
Shopova, S. I.
Smith, H.
Smith, T.
Smith, T. L.
Suter, J. D.
Thomas, T. P.
Trau, M.
Tu, X.
Turner, A.
Vahala, K.
Vogel, R.
Vollmer, F.
Wan, Z.
Wang, S.
White, I. M.
Willmott, G.
Xiao, Y.-F.
Xu, L.
Yang, L.
Ye, J. Y.
Yi, Y.
Zhang, J.
Zhang, J.-Y.
Zhu, H.
Zhu, J.
Zin, M.
Znameroski, S.
Zourob, M.

Anal. Chem.

R. Vogel, G. Willmott, D. Kozak, G. S. Roberts, W. Anderson, L. Groenewegen, B. Glossop, A. Barnett, A. Turner, and M. Trau, “Quantitative sizing of nano/microparticles with a tunable elastomeric pore sensor,” Anal. Chem.83(9), 3499–3506 (2011). [CrossRef] [PubMed]
Y. Guo, J. Y. Ye, C. Divin, B. Huang, T. P. Thomas, J. R. Baker, and T. B. Norris, “Real-time biomolecular binding detection using a sensitive photonic crystal biosensor,” Anal. Chem.82(12), 5211–5218 (2010). [CrossRef] [PubMed]

Analyst (Lond.)

H. Zhu, I. M. White, J. D. Suter, M. Zourob, and X. Fan, “Opto-fluidic micro-ring resonator for sensitive label-free viral detection,” Analyst (Lond.)133(3), 356–360 (2008). [CrossRef] [PubMed]

Appl. Phys. Lett.

B. Koch, Y. Yi, J.-Y. Zhang, S. Znameroski, and T. Smith, “Reflection-mode sensing using optical microresonators,” Appl. Phys. Lett.95(20), 201111 (2009). [CrossRef]
S. Wang, K. Broderick, H. Smith, and Y. Yi, “Strong coupling between on chip notched ring resonator and nanoparticle,” Appl. Phys. Lett.97(5), 051102 (2010). [CrossRef]
V. R. Dantham, S. Holler, V. Kolchenko, Z. Wan, and S. Arnold, “Taking whispering gallery-mode single virus detection and sizing to the limit,” Appl. Phys. Lett.101(4), 043704 (2012). [CrossRef]
I. M. White, H. Oveys, X. Fan, T. L. Smith, and J. Zhang, “Integrated multiplexed biosensors based on liquid core optical ring resonators and antiresonant reflecting optical waveguides,” Appl. Phys. Lett.89(19), 191106 (2006). [CrossRef]

Biomed. Opt. Express

A. Haddadpour and Y. Yi, “Metallic nanoparticle on micro ring resonator for bio optical detection and sensing,” Biomed. Opt. Express1(2), 378–384 (2010). [CrossRef] [PubMed]

J. Am. Chem. Soc.

H. Li, L. Shang, X. Tu, L. Liu, and L. Xu, “Coupling variation induced ultrasensitive label-free biosensing by using single mode coupled microcavity laser,” J. Am. Chem. Soc.131(46), 16612–16613 (2009). [CrossRef] [PubMed]

J. Lightwave Technol.

B. E. Little, J.-P. Laine, and H. A. Haus, “Analytic theory of coupling from tapered fibers and half-blocks into microsphere resonators,” J. Lightwave Technol.17(4), 704–715 (1999). [CrossRef]

Nat. Nanotechnol.

L. He, Ş. K. Özdemir, J. Zhu, W. Kim, and L. Yang, “Detecting single viruses and nanoparticles usingwhispering gallery microlasers,” Nat. Nanotechnol.6(7), 428 (2011). [CrossRef]

Nat. Photonics

J. Zhu, S. K. Ozdemir, Y.-F. Xiao, L. Li, L. He, D.-R. Chen, and L. Yang, “On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator,” Nat. Photonics4(1), 46–49 (2010). [CrossRef]

Opt. Express

J. Zhu, Ş. K. Özdemir, L. He, D.-R. Chen, and L. Yang, “Single virus and nanoparticle size spectrometry by whispering-gallery-mode microcavities,” Opt. Express19(17), 16195–16206 (2011). [CrossRef] [PubMed]

Proc. Natl. Acad. Sci. U.S.A.

T. Lu, H. Lee, T. Chen, S. Herchak, J.-H. Kim, S. E. Fraser, R. C. Flagan, and K. Vahala, “High sensitivity nanoparticle detection using optical microcavities,” Proc. Natl. Acad. Sci. U.S.A.108(15), 5976–5979 (2011). [CrossRef] [PubMed]
F. Vollmer, S. Arnold, and D. Keng, “Single virus detection from the reactive shift of a whispering-gallery mode,” Proc. Natl. Acad. Sci. U.S.A.105(52), 20701–20704 (2008). [CrossRef] [PubMed]

Rev. Sci. Instrum.

S. I. Shopova, R. Rajmangal, Y. Nishida, and S. Arnold, “Ultrasensitive nanoparticle detection using a portable whispering gallery mode biosensor driven by a periodically poled lithium-niobate frequency doubled distributed feedback laser,” Rev. Sci. Instrum.81(10), 103110 (2010). [CrossRef] [PubMed]

Sens. Actuators B Chem.

B. Koch, L. Carson, C.-M. Guo, C.-Y. Lee, Y. Yi, J.-Y. Zhang, M. Zin, S. Znameroski, and T. Smith, “Hurricane: A simplified optical resonator for optical-power-based sensing with nano-particle taggants,” Sens. Actuators B Chem.147(2), 573–580 (2010).

Small

G. S. Roberts, D. Kozak, W. Anderson, M. F. Broom, R. Vogel, and M. Trau, “Tunable nano/micropores for particle detection and discrimination: Scanning ion occlusion spectroscopy,” Small6(23), 2653–2658 (2010). [CrossRef] [PubMed]

Other

K. Okamoto, Fundamentals of Optical Waveguides (Academic Press, 2000).

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