OSA's Digital Library

Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 21 — Oct. 21, 2013
  • pp: 25480–25491

Snapshot molecular imaging using coded energy-sensitive detection

Joel A. Greenberg, Kalyani Krishnamurthy, and David Brady  »View Author Affiliations


Optics Express, Vol. 21, Issue 21, pp. 25480-25491 (2013)
http://dx.doi.org/10.1364/OE.21.025480


View Full Text Article

Enhanced HTML    Acrobat PDF (4149 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We demonstrate a technique for measuring the range-resolved coherent scatter form factors of different objects from a single snapshot. By illuminating the object with an x-ray pencil beam and placing a coded aperture in front of a linear array of energy-sensitive detector elements, we record the coherently scattered x-rays. This approach yields lateral, range, and momentum transfer resolutions of 1 mm, 5 mm, and 0.2 nm−1, respectively, which is sufficient for the distinguishing a variety of solids and liquids. These results indicate a path toward real-time volumetric molecular imaging for non-destructive examination in a variety of applications, including medical diagnostics, quality inspection, and security detection.

© 2013 OSA

OCIS Codes
(110.7440) Imaging systems : X-ray imaging
(340.7430) X-ray optics : X-ray coded apertures
(110.1758) Imaging systems : Computational imaging
(110.3200) Imaging systems : Inverse scattering

ToC Category:
Imaging Systems

History
Original Manuscript: August 30, 2013
Revised Manuscript: October 4, 2013
Manuscript Accepted: October 9, 2013
Published: October 17, 2013

Citation
Joel A. Greenberg, Kalyani Krishnamurthy, and David Brady, "Snapshot molecular imaging using coded energy-sensitive detection," Opt. Express 21, 25480-25491 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-21-25480


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. J.-P. Schlomka, A. Harding, U. van Stevendaal, M. Grass, and G. L. Harding, “Coherent scatter computed tomography: a novel medical imaging technique,” Proc. SPIE 5030, Medical Imaging 2003: Physics of Medical Imaging pp. 256–265 (2003). URL + http://dx.doi.org/10.1117/12.479949 . [CrossRef]
  2. G. Harding and B. Schreiber, “Coherent X-ray scatter imaging and its applications in biomedical science and industry,” Radiation Phys. Chem.56(12), 229–245 (1999). URL http://www.sciencedirect.com/science/article/pii/S0969806X99002832 . [CrossRef]
  3. B. Sun, M. Li, F. Zhang, Y. Zhong, N. Kang, W. Lu, and J. Liu, “The performance of a fast testing system for illicit materials detection based on energy-dispersive X-ray diffraction technique,” Microchem. J.95(2), 293–297 (2010). URL http://www.sciencedirect.com/science/article/pii/S0026265X10000056 . [CrossRef]
  4. D. O’Flynn, C. B. Reid, C. Christodoulou, M. D. Wilson, M. C. Veale, P. Seller, D. Hills, H. Desai, B. Wong, and R. Speller, “Explosive detection using pixellated X-ray diffraction (PixD),” J. Instrumen.8(03), P03007 (2013). URL http://stacks.iop.org/1748-0221/8/i=03/a=P03007 . [CrossRef]
  5. A. Dicken, K. Rogers, P. Evans, J. Rogers, and J. W. Chan, “The separation of X-ray diffraction patterns for threat detection,” Appl. Radia. Isotopes68(3), 439–443 (2010). URL http://www.sciencedirect.com/science/article/pii/S0969804309007611 . [CrossRef]
  6. J. Hogan, R. Gonsalves, and A. Krieger, “Fluorescent computer tomography: a model for correction of X-ray absorption,” IEEE Trans. Nuclear Sci.38(6), 1721–1727 (1991).
  7. S. D. M. Jacques, C. K. Egan, M. D. Wilson, M. C. Veale, P. Seller, and R. J. Cernik, “A laboratory system for element specific hyperspectral X-ray imaging,” Analyst138, 755–759 (2013). URL http://dx.doi.org/10.1039/C2AN36157D . [CrossRef]
  8. H. Yan, Y. S. Chu, J. Maser, E. Nazaretski, J. Kim, J. J. Lombardo, and W. K. S. Chiu, “Quantitative x-ray phase imaging at the nanoscale by multilayer Laue lenses,” Sci. Rep.3, 1307 (2013). [CrossRef] [PubMed]
  9. G. Harding and J. Kosanetzky, “Status and outlook of coherent-x-ray scatter imaging,” J. Opt. Soc. Am. A4(5), 933–944 (1987). URL http://josaa.osa.org/abstract.cfm?URI=josaa-4-5-933 . [CrossRef] [PubMed]
  10. B. W. King, K. A. Landheer, and P. C. Johns, “X-ray coherent scattering form factors of tissues, water and plastics using energy dispersion,” Phys. Med. Biol.56(14), 4377 (2011). URL http://stacks.iop.org/0031-9155/56/i=14/a=010 . [CrossRef] [PubMed]
  11. J. Delfs and J.-P. Schlomka, “Energy-dispersive coherent scatter computed tomography,” Appl. Phys. Lett.88(24), 243506–243508 (2006). URL http://link.aip.org/link/?APL/88/243506/1 . [CrossRef]
  12. G. Harding, M. Newton, and J. Kosanetzky, “Energy-dispersive X-ray diffraction tomography,” Phys. Med. Biol.35(1), 33 (1990). URL http://stacks.iop.org/0031-9155/35/i=1/a=004 . [CrossRef]
  13. A. Dicken, K. Rogers, P. Evans, J. W. Chan, J. Rogers, and S. Godber, “Combined X-ray diffraction and kinetic depth effect imaging,” Opt. Express19(7), 6406–6413 (2011). URL http://www.opticsexpress.org/abstract.cfm?URI=oe-19-7-6406 . [CrossRef] [PubMed]
  14. K. MacCabe, K. Krishnamurthy, A. Chawla, D. Marks, E. Samei, and D. Brady, “Pencil beam coded aperture x-ray scatter imaging,” Opt. Express20(15), 16310–16320 (2012). URL http://www.opticsexpress.org/abstract.cfm?URI=oe-20-15-16310 . [CrossRef]
  15. K. P. MacCabe, A. D. Holmgren, M. P. Tornai, and D. J. Brady, “Snapshot 2D tomography via coded aperture x-ray scatter imaging,” Appl. Opt.52(19), 4582–4589 (2013). URL http://ao.osa.org/abstract.cfm?URI=ao-52-19-4582 . [CrossRef] [PubMed]
  16. R. D. Speller, J. A. Horrocks, and R. J. Lacey, “X-ray scattering signatures for material identification,” Proc. SPIE 2092, Substance Detection Systems pp. 366–377 (1994). URL + http://dx.doi.org/10.1117/12.171256 . [CrossRef]
  17. L. I. Rudin, S. Osher, and E. Fatemi, “Nonlinear total variation based noise removal algorithms,” Physica D: Nonlinear Phenomena60(1), 259–268 (1992). [CrossRef]
  18. P. Getreuer, “Rudin-Osher-Fatemi Total Variation Denoising using Split Bregman,” Image Processing On Line10(2012).
  19. S. Rutishauser, M. Bednarzik, I. Zanette, T. Weitkamp, M. Brner, J. Mohr, and C. David, “Fabrication of two-dimensional hard X-ray diffraction gratings,” Microelectron. Eng.101(0), 12–16 (2013). URL http://www.sciencedirect.com/science/article/pii/S0167931712004935 . [CrossRef]
  20. B. W. King and P. C. Johns, “Measurement of coherent scattering form factors using an image plate,” Phys. Med. Biol.54(20), 6437 (2009). URL http://stacks.iop.org/0031-9155/54/i=20/a=C01 . [CrossRef]
  21. J. A. Greenberg, K. Krishnamurthy, M. Lakshmanan, K. MacCabe, S. Wolter, A. Kapadia, and D. Brady, “Coding and sampling for compressive x-ray diffraction tomography,” Proc. SPIE8858, 885813 (2013). URL http://dx.doi.org/10.1117/12.2027128 . [CrossRef]
  22. P. Seller, S. Bell, R. J. Cernik, C. Christodoulou, C. K. Egan, J. A. Gaskin, S. Jacques, S. Pani, B. D. Ramsey, C. Reid, P. J. Sellin, J. W. Scuffham, R. D. Speller, M. D. Wilson, and M. C. Veale, “Pixellated Cd(Zn)Te high-energy X-ray instrument,” J. Instrumen.6(12), C12,009 (2011). URL http://stacks.iop.org/1748-0221/6/i=12/a=C12009 .

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited