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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 21, Iss. 25 — Dec. 16, 2013
  • pp: 30849–30858

Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging

Ali M. Fard, Paulino Vacas-Jacques, Ehsan Hamidi, Hao Wang, Robert W. Carruth, Joseph A. Gardecki, and Guillermo J. Tearney  »View Author Affiliations


Optics Express, Vol. 21, Issue 25, pp. 30849-30858 (2013)
http://dx.doi.org/10.1364/OE.21.030849


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Abstract

Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dual-modality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver human coronary artery.

© 2013 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics
(110.0113) Imaging systems : Imaging through turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: September 17, 2013
Revised Manuscript: October 27, 2013
Manuscript Accepted: November 7, 2013
Published: December 6, 2013

Virtual Issues
Vol. 9, Iss. 2 Virtual Journal for Biomedical Optics

Citation
Ali M. Fard, Paulino Vacas-Jacques, Ehsan Hamidi, Hao Wang, Robert W. Carruth, Joseph A. Gardecki, and Guillermo J. Tearney, "Optical coherence tomography – near infrared spectroscopy system and catheter for intravascular imaging," Opt. Express 21, 30849-30858 (2013)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-21-25-30849


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