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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 13 — Jun. 30, 2014
  • pp: 15397–15409

Simple model for plasmon enhanced fluorescence correlation spectroscopy

Lutz Langguth and A. Femius Koenderink  »View Author Affiliations


Optics Express, Vol. 22, Issue 13, pp. 15397-15409 (2014)
http://dx.doi.org/10.1364/OE.22.015397


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Abstract

Metallic nano-antennas provide strong field confinement and intensity enhancement in hotspots and thus can ultimately enhance fluorescence detection and provide ultra small detection volumes. In solution-based fluorescence measurements, the diffraction limited focus driving the nano-antenna can outshine the fluorescence originating from the hotspot and thus render the benefits of the hotspot negligible. We introduce a model to calculate the effect of a nano-antenna, or any other object creating a nontrivial intensity distribution, for fluorescence fluctuation measurements. Approximating the local field enhancement of the nano-antenna by a 3D Gaussian profile, we show which hotspot sizes and intensities are the most beneficial for an FCS measurement and compare it to realistic antenna parameters from literature.

© 2014 Optical Society of America

OCIS Codes
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
(350.4238) Other areas of optics : Nanophotonics and photonic crystals
(310.6628) Thin films : Subwavelength structures, nanostructures

ToC Category:
Spectroscopy

History
Original Manuscript: April 25, 2014
Revised Manuscript: May 30, 2014
Manuscript Accepted: May 30, 2014
Published: June 17, 2014

Virtual Issues
Vol. 9, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Lutz Langguth and A. Femius Koenderink, "Simple model for plasmon enhanced fluorescence correlation spectroscopy," Opt. Express 22, 15397-15409 (2014)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-13-15397


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