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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 3 — Feb. 10, 2014
  • pp: 2414–2422

Luminescence and photosensitivity of gadolinium labeled hematoporphyrin monomethyl ether

Peng Wang, Feng Qin, Li Wang, Fajun Li, Yangdong Zheng, Yunfei Song, Zhiguo Zhang, and Wenwu Cao  »View Author Affiliations

Optics Express, Vol. 22, Issue 3, pp. 2414-2422 (2014)

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Photodynamic therapy for deep-lying lesions needs an appropriate imaging modality, precise evaluation of tissue oxygen and an effective photosensitizer. Gadolinium based metalloporphyrins Gd(III)-HMME is proposed in this study as a potential multifunctional theranostic agent, as photosensitizer, ratiometric oxygen sensor and MRI contrast agent. The time resolved spectroscopy revealed the luminescence peak of Gd(III)-HMME at 710 and 779 nm with a lifetime of 64 μs in oxygen-free methanol to be phosphorescent. This phosphorescence is strongly dependent on dissolved oxygen concentration. Its intensity in oxygen saturated methanol solution is 21% of that in deoxygenated solution. The singlet oxygen quantum yields ΦΔ of HMME and Gd(III)-HMME in air saturated methanol solution were determined to be 0.79 and 0.40 respectively using comparative spectra method. These phenomena indicate that the oxygen sensibility and production of singlet oxygen of Gd(III)-HMME can fulfill the requirement of PDT treatment.

© 2014 Optical Society of America

OCIS Codes
(160.4760) Materials : Optical properties
(160.5690) Materials : Rare-earth-doped materials
(300.6500) Spectroscopy : Spectroscopy, time-resolved
(160.1435) Materials : Biomaterials

ToC Category:

Original Manuscript: November 14, 2013
Revised Manuscript: December 27, 2013
Manuscript Accepted: December 29, 2013
Published: January 28, 2014

Virtual Issues
Vol. 9, Iss. 4 Virtual Journal for Biomedical Optics

Peng Wang, Feng Qin, Li Wang, Fajun Li, Yangdong Zheng, Yunfei Song, Zhiguo Zhang, and Wenwu Cao, "Luminescence and photosensitivity of gadolinium labeled hematoporphyrin monomethyl ether," Opt. Express 22, 2414-2422 (2014)

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