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Optics Express

Optics Express

  • Editor: Andrew M. Weiner
  • Vol. 22, Iss. 7 — Apr. 7, 2014
  • pp: 8085–8093

Conformation sequence recovery of a non-periodic object from a diffraction-before-destruction experiment

Chun Hong Yoon, Miriam Barthelmess, Richard J. Bean, Flavio Capotondi, Richard A. Kirian, Maya Kiskinova, Emanuele Pedersoli, Lorenzo Raimondi, Francesco Stellato, Fenglin Wang, and Henry N. Chapman  »View Author Affiliations


Optics Express, Vol. 22, Issue 7, pp. 8085-8093 (2014)
http://dx.doi.org/10.1364/OE.22.008085


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Abstract

Knowledge of the sequence of different conformational states of a protein molecule is key to better understanding its biological function. A diffraction pattern from a single conformational state can be captured with an ultrafast X-ray Free-Electron Laser (XFEL) before the target is completely annihilated by the radiation. In this paper, we report the first experimental demonstration of conformation sequence recovery using diffraction patterns from randomly ordered conformations of a non-periodic object using the dimensional reduction technique Isomap and coherent diffraction imaging.

© 2014 Optical Society of America

OCIS Codes
(150.0150) Machine vision : Machine vision
(260.1960) Physical optics : Diffraction theory
(290.5840) Scattering : Scattering, molecules
(320.7100) Ultrafast optics : Ultrafast measurements

ToC Category:
Diffraction and Gratings

History
Original Manuscript: January 24, 2014
Revised Manuscript: March 18, 2014
Manuscript Accepted: March 18, 2014
Published: March 31, 2014

Citation
Chun Hong Yoon, Miriam Barthelmess, Richard J. Bean, Flavio Capotondi, Richard A. Kirian, Maya Kiskinova, Emanuele Pedersoli, Lorenzo Raimondi, Francesco Stellato, Fenglin Wang, and Henry N. Chapman, "Conformation sequence recovery of a non-periodic object from a diffraction-before-destruction experiment," Opt. Express 22, 8085-8093 (2014)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-22-7-8085


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