Abstract

We theoretically and experimentally demonstrate an ultrasensitive two-dimensional photonic crystal microcavity biosensor. The device is fabricated on a silicon-on-insulator wafer and operates near its resonance at 1.58 μm. Coating the sensor internal surface with proteins of different sizes produces a different amount of resonance redshift. The present device can detect a molecule monolayer with a total mass as small as 2.5 fg. The device performance is verified by measuring the redshift corresponding to the binding of glutaraldehyde and bovine serum albumin (BSA). The experimental results are in good agreement with theory and with ellipsometric measurements performed on a flat oxidized silicon wafer surface.

© 2007 Optical Society of America

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History
Original Manuscript: January 18, 2007
Manuscript Accepted: March 23, 2007
Revised Manuscript: March 23, 2007
Published: April 3, 2007

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Author Affiliations

Philippe M. Fauchet

Department of Electrical and Computer Engineering, University of Rochester

Mindy R. Lee

The Institute of Optics, University of Rochester

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