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Optics Express

Optics Express

  • Editor: C. Martijn de Sterke
  • Vol. 15, Iss. 18 — Sep. 3, 2007
  • pp: 11095–11116

Optics InfoBase > Optics Express > Volume 15 > Issue 18 > Image reconstruction for bioluminescence tomography from partial measurement

Image reconstruction for bioluminescence tomography from partial measurement

Ming Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, and Ge Wang  »View Author Affiliations

Optics Express, Vol. 15, Issue 18, pp. 11095-11116 (2007)

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The bioluminescence tomography is a novel molecular imaging technology for small animal studies. Known reconstruction methods require the completely measured data on the external surface, although only partially measured data is available in practice. In this work, we formulate a mathematical model for BLT from partial data and generalize our previous results on the solution uniqueness to the partial data case. Then we extend two of our reconstruction methods for BLT to this case. The first method is a variant of the well-known EM algorithm. The second one is based on the Landweber scheme. Both methods allow the incorporation of knowledgebased constraints. Two practical constraints, the source non-negativity and support constraints, are introduced to regularize the BLT problem and produce stability. The initial choice of both methods and its influence on the regularization and stability are also discussed. The proposed algorithms are evaluated and validated with intensive numerical simulation and a physical phantom experiment. Quantitative results including the location and source power accuracy are reported. Various algorithmic issues are investigated, especially how to avoid the inverse crime in numerical simulations.

© 2007 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 9, 2007
Revised Manuscript: July 17, 2007
Manuscript Accepted: August 16, 2007
Published: August 20, 2007

Virtual Issues
Vol. 2, Iss. 10 Virtual Journal for Biomedical Optics

Ming Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, and Ge Wang, "Image reconstruction for bioluminescence tomography from partial measurement," Opt. Express 15, 11095-11116 (2007)

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