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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 1, Iss. 13 — Dec. 22, 1997
  • pp: 404–413

A fundamental limitation of linearized algorithms for diffuse optical tomography

D. A. Boas  »View Author Affiliations


Optics Express, Vol. 1, Issue 13, pp. 404-413 (1997)
http://dx.doi.org/10.1364/OE.1.000404


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Abstract

Diffuse Optical Tomography is rapidly developing as a new imaging modality for characterizing the spatially varying optical properties of media which strongly scatter light (e.g. tissue). Numerous imaging algorithms exist, and more are being developed. Many of these algorithms rely on assumptions which linearize the relationship between the optical contrast and the perturbed signal. We show that this linear approximation makes quantitative imaging of spatially varying optical properties impossible. The explanation for this result is presented and the implication for Diffuse Optical Tomography is discussed.

© Optical Society of America

OCIS Codes
(170.5270) Medical optics and biotechnology : Photon density waves
(170.5280) Medical optics and biotechnology : Photon migration
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Focus Issue: Biomedical optics

History
Original Manuscript: October 8, 1997
Revised Manuscript: October 8, 1997
Published: December 22, 1997

Citation
David Boas, "A fundamental limitation of linearized algorithms for diffuse optical tomography," Opt. Express 1, 404-413 (1997)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-1-13-404


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