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Optics Express

Optics Express

  • Editor: J. H. Eberly
  • Vol. 1, Iss. 13 — Dec. 22, 1997
  • pp: 432–440

In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa

A. M. Sergeev, V. M. Gelikonov, G. V. Gelikonov, F. I. Feldchtein, R. V. Kuranov, N. D. Gladkova, N. M. Shakhova, L. B. Snopova, A. V. Shakhov, I. A. Kuznetzova, A. N. Denisenko, V. V. Pochinko, Yu. P. Chumakov, and O. S. Streltzova  »View Author Affiliations


Optics Express, Vol. 1, Issue 13, pp. 432-440 (1997)
http://dx.doi.org/10.1364/OE.1.000432


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Abstract

First results of endoscopic applications of optical coherence tomography for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and body as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue are distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

© Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Focus Issue: Biomedical optics

History
Original Manuscript: October 8, 1997
Revised Manuscript: October 3, 1997
Published: December 22, 1997

Citation
Alexander Sergeev, V. Gelikonov, G. Gelikonov, Felix Feldchtein, R. Kuranov, N. Gladkova, N. Shakhova, L. Snopova, A. Shakhov, I. Kuznetzova, A. Denisenko, V. Pochinko, Yu Chumakov, and O. Streltzova, "In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa," Opt. Express 1, 432-440 (1997)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-1-13-432


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References

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