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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 10, Iss. 15 — Jul. 29, 2002
  • pp: 707–713

Complementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues

R. V. Kuranov, V. V. Sapozhnikova, I. V. Turchin, E. V. Zagainova, V. M. Gelikonov, V. A. Kamensky, L. B. Snopova, and N. N. Prodanetz  »View Author Affiliations


Optics Express, Vol. 10, Issue 15, pp. 707-713 (2002)
http://dx.doi.org/10.1364/OE.10.000707


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Abstract

An experimental standard optical coherence tomography (OCT) setup that can be easily modified for cross-polarization OCT (CP OCT) operation has been developed to perform differential diagnosis of pathological tissues. The complementary use of CP OCT, a technique that provides a map of cross-polarization backscattering properties of an object being studied by means of low-coherence interferometry, and standard OCT imaging improves the specificity of diagnostics of pathological changes occurring in tissues. It is shown that healthy, neoplastic and scar tissues of the esophagus have different cross-polarization backscattering properties. A comparative analysis of CP OCT, OCT and histological images from one and the same tissue area has been made. A close correlation between the location of collagen fibers in biological tissue and signal intensity in CP OCT images is found.

© 2002 Optical Society of America

OCIS Codes
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(260.5430) Physical optics : Polarization

ToC Category:
Research Papers

History
Original Manuscript: June 5, 2002
Revised Manuscript: July 16, 2002
Published: July 29, 2002

Citation
Roman Kuranov, V. Sapozhnikova, I. Turchin, E. Zagainova, V. Gelikonov, V. Kamensky, L. Snopova, and N. Prodanetz, "Complementary use of cross-polarization and standard OCT for differential diagnosis of pathological tissues," Opt. Express 10, 707-713 (2002)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-10-15-707


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