OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 10, Iss. 3 — Feb. 11, 2002
  • pp: 171–176

Intratissue surgery with 80 MHz nanojoule femtosecond laser pulses in the near infrared

Karsten König, Oliver Krauss, and Iris Riemann  »View Author Affiliations

Optics Express, Vol. 10, Issue 3, pp. 171-176 (2002)

View Full Text Article

Enhanced HTML    Acrobat PDF (1750 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



The use of 1 nanojoule near infrared 80 MHz femtosecond laser pulses for highly precise intratissue processing, in particular for intraocular refractive surgery, was evaluated. Destructive optical breakdown at TW/cm2 light intensities in a subfemtoliter intrastromal volume was obtained by diffraction-limited focussing with an 40x objective (N.A. 1.3) and beam scanning 50 to 140 μm below the epithelial surface. Using the same system at GW/cm2 intensities two-photon excited autofluorescence imaging was used to determine the target of interest and to visualize intraocular laser effects. Histological examination of laser-exposed porcine eyes reveal a minimum cut size below 1 μm without destructive effects to surrounding tissues.

© Optical Society of America

OCIS Codes
(140.7090) Lasers and laser optics : Ultrafast lasers
(170.1020) Medical optics and biotechnology : Ablation of tissue

ToC Category:
Research Papers

Original Manuscript: January 4, 2002
Revised Manuscript: January 31, 2002
Published: February 11, 2002

Karsten Koenig, Oliver Krauss, and Iris Riemann, "Intratissue surgery with 80 MHz nanojoule femtosecond laser pulses in the near infrared," Opt. Express 10, 171-176 (2002)

Sort:  Journal  |  Reset  


  1. I. G. Pallikaris and D. S. Saiganos, ?Excimer laser in situ keratomileusis and photorefractive keratectomy for correction of high myopia," J. Refract. Surg. 10, 498-510 (1994).
  2. M. Mrochen, M. Kaemmerer and T. Seiler, ?Wavefront-guided laser in situ keratomileusis: early results in three eyes,? J. Refrac. Surg. 16, 116-121 (2000).
  3. D. Stern, C. A. Puliafito, E. T. Dobei andW. T. Reidy, ?Corneal ablation by nanosecond, picosecond and femtosecond laser pulses at 532 nm and 625 nm,? Arch. Ophthalmol. 107, 587-592 (1989). [CrossRef] [PubMed]
  4. R. M. Kurtz, C. Horvath, H. H. Liu, R. R. Krueger and T. Juhasz, ?Lamellar refractive surgery with scanned intrastromal picosecond and femtosecond laser pulses in animal eyes,? J. Refract. Surg. 14, 541-548 (1998). [PubMed]
  5. A. Vogel, K. Nahen, D. Theisen, R. Birngruber, R. J. Thomas and B. A. Rockwell, ?Energy balance of optical breakdown in water at nanosecond to femtosecond time scales,? Appl. Phys. B 68, 271-280 (1999). [CrossRef]
  6. R. M. Kurtz, X. Liu, V. M. Elner, J. A. Squier, D. Du and G. A. Mourou, ?Photodisruption in the human cornea as a function of laser pulse width,? J. Refract. Surg. 13, 653-658 (1997).
  7. M. Ito, A. J. Quantock, S. Malhan, D. J. Schanzlin and R. R. Krueger, ?Picosecond laser in situ keratomileusis with a 1053-nm Nd:YLF laser,? J. Refract. Surg. 12, 721-728 (1996). [PubMed]
  8. H. Gimbel, S. Coupland and M. Ferensowisc, ?Review of intrastromal photorefractive keratectomy with the neodymium-yttrium lithium fluoride laser,? Int. Ophthalmol. Clin. 37, 95-102 (1997). [CrossRef] [PubMed]
  9. H. Lubatschowski, G. Maatz, A. Heisterkamp, U. Hetzel, W. Drommer, H. Welling and W. Ertmer, "Application of ultrashort laser pulses for intrastromal refractive surgery,? Graefe?s Arch. Clin. Exp. Ophthalmol. 238, 33-39 (2000). [CrossRef]
  10. J. Noack and A. Vogel, ?Laser-induced plasma formation in water at nanosecond to femtosecond time scales: calculation of thresholds, absorption coefficients, and energy densities,? IEEE J. Quantum Electron. 35, 1156-1167 (1999). [CrossRef]
  11. T. Juhasz, G. A. Kastis, C. Suarez, Z. Bor and W.E. Brown, ?Time-resolved observations of shock waves and cavitation bubbles generated by femtosecond laser pulses in corneal tissue and water,? Lasers Surg. Med. 19, 23-31(1996). [CrossRef] [PubMed]
  12. T. Juhasz, F. H. Loesel, R. M. Kurtz, C. Horvath, J. F. Bille and G. Mourou, ?Corneal refractive surgery with femtosecond lasers,? IEEE J. Quantum Electron. 5, 902-909 (1999). [CrossRef]
  13. K. K?nig, I. Riemann and W. Fritzsche, "Nanodissection of human chromosomes with near-infrared femtosecond laser pulses,? Opt. Lett. 26, 819-821 (2001). [CrossRef]
  14. K. K?nig, "Multiphoton microscopy in life sciences," J. Microsc. 200, 83-104 (2000). [CrossRef] [PubMed]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


Fig. 1. Fig. 2.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited