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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 10 — May. 19, 2003
  • pp: 1223–1236

Multispectral digital colposcopy for in vivo detection of cervical cancer

Juan Manuel Benavides, Sung Chang, Sun Young Park, Rebecca Richards-Kortum, Nick Mackinnon, Calum MacAulay, Andrea Milbourne, Anais Malpica, and Michele Follen  »View Author Affiliations


Optics Express, Vol. 11, Issue 10, pp. 1223-1236 (2003)
http://dx.doi.org/10.1364/OE.11.001223


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Abstract

We present a multispectral digital colposcope (MDC) to measure multispectral autofluorescence and reflectance images of the cervix by using an inexpensive color CCD camera. The diagnostic ability of the MDC was evaluated by application of MDC spectral response to fluorescence and reflectance spectra measured from a large clinical trial. High diagnostic performance was achieved by use of only two excitation wavelengths: 330 and 440 nm. Good quality autofluorescence images of the human cervix were acquired in vivo with the MDC. Automated diagnostic algorithms correctly identified CIN (cervical intraepithelial neoplasia) lesions from MDC fluorescence images. The MDC has the potential to provide a cost-effective alternative to standard colposcopy and better direction of biopsies.

© 2003 Optical Society of America

OCIS Codes
(110.2970) Imaging systems : Image detection systems
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6510) Medical optics and biotechnology : Spectroscopy, tissue diagnostics

ToC Category:
Research Papers

History
Original Manuscript: March 28, 2003
Revised Manuscript: May 11, 2003
Published: May 19, 2003

Citation
Juan Benavides, Sung Chang, Sun Park, Rebecca Richards-Kortum, Nick Mackinnon, Calum MacAulay, Andrea Milbourne, Anais Malpica, and Michele Follen, "Multispectral digital colposcopy for in vivo detection of cervical cancer," Opt. Express 11, 1223-1236 (2003)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-11-10-1223


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References

  1. Cancer Facts and Figures, American Society of Cancer, 2001.
  2. International Agency for Research in Cancer, 2002.
  3. L. G. Koss, �??The Papanicoloau test for cervical cancer detection: a triumph and a tragedy,�?? J. Am. Med. Assoc. 261, 737-743 (1989). [CrossRef]
  4. M. F. Mitchell, D. Schottenfeld, G. Tortolero-Luna, S. B. Cantor, R. and Richards-Kortum, �??Colposcopy for the diagnosis of squamous intraepithelial lesions: a meta-analysis,�?? Obstet. Gynecol. 91, 626-631 (1998). [CrossRef] [PubMed]
  5. M. F. Mitchell, �??Preinvasive diseases of the female low genital track,�?? in Operative Gynecology D. M. Greshenson, A. DeCherney, and S. Curry, eds. (Saunders, Philadelphia, 1993), p. 231.
  6. R. J. Kurman, D. E. Herison, A. L. Herbst, K. L. Noller, and M. H. Schiffman, �??Interim guidelines for management of abnormal cervical cytology,�?? J. Am. Med. Assoc. 271, 1866-1869 (1994). [CrossRef]
  7. S. B. Cantor, M. Follen-Mitchell, G. Tortolero-Luna, C. Bratka, D. Bodurka, and R. Richards-Kortum, �??Cost-effectiveness analysis of diagnosis and management of cervical squamous intraepithelial lesions,�?? Obstet. Gynecol. 91, 270-277 (1998). [CrossRef] [PubMed]
  8. N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. C. Wright, N. Atkinson, and R. R. Richards-Kortum, �??In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laserinduced fluorescence,�?? Proc. Natl. Acad. Sci. USA 91, 10193-10197 (1994). [CrossRef] [PubMed]
  9. N. Ramanujam, M. F. Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. C. Wright, N. Atkinson, and R. R. Richards-Kortum, �??Spectroscopic diagnosis of cervical intraepithelial neoplasia (CIN) in vivo using laser induced fluorescence spectra at multiple excitation wavelengths,�?? Lasers Surg. Med. 19, 63-74 (1996). [CrossRef] [PubMed]
  10. N. Ramanujam, M. F. Mitchell, A. Mahadevan-Jansen, S. Thomsen, G. Staerkel, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, �??Cervical pre-cancer detection using a multivariate statistical algorithm based on laser induced fluorescence spectra at multiple excitation wavelengths,�?? Photochem. Photobiol. 6, 720-735 (1996). [CrossRef]
  11. A. K. Dattamajumdar, D. Wells, J. Parnell, J. T. Lewis, D. Ganguly, and T. C. Jr. Wright, �??Preliminary experimental results from multi-center clinical trials for detection of cervical precancerous lesions using the Cerviscan system: a novel full-field evoked tissue fluorescence based imaging instruments,�?? in 23rd Annual Meeting of IEEE-Engineering in Medicine and Biology, Istanbul, Turkey, October 2001.
  12. I. Georgakoudi, B. C. Jacobson, M. G. Muller, E. E. Sheets, D. Badizadegan, D. L. Carr-Locke, C. P. Crum, C. W. Boone, R. R. Dasari, J. Van Dam, and M. S. Feld, �??,�?? Cancer Res. 62, 682-687 (2002). [PubMed]
  13. R. Drezek, K. Sokolov, U. Utzinger, I. Boiko, A. Malpica, M. Follen, and R. Richards-Kortum, �??Understanding the contributions of NADH and collagen to cervical tissue fluorescence spectra: Modeling, measurements, and implications,�?? J. Biomed. Opt. 6, 385-396 (2001). [CrossRef] [PubMed]
  14. I. Pavlova, K. Sokolov, A. Drezek, A. Malpica, M. Follen, and R. Richards-Kortum, �??Microanatomical and biochemical origins of normal and precancerous cervical autofluorescence using laser scanning fluorescence confocal microscopy,�?? submitted to Photochem. Photobiol. (2002).
  15. N. Ramanujam, �??Fluorescence spectroscopy of neoplastic and non-neoplastic tissues,�?? Neoplasia 2(1), 89- 117, (2000). [CrossRef] [PubMed]
  16. I. Georgakoudi, B. C. Jacobson, J. Van Dam, V. Backman, M. B. Wallace, M.G. Muller, Q. Zhang, K. Badizadegan, D. Sun, G. Thomas, L. T. Perelman, and M. S. Feld, �??Fluorescence, reflectance, and lightscattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus,�?? Gastroenterology 120, 1620-1629 (2001). [CrossRef] [PubMed]
  17. R. J. Nordstrom, L. Burke, J. M. Niloff, and J. F. Myrtle, �??Identification of cervical intraepithelial neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy,�?? Lasers Surg. Med. 29, 118-127 (2001). [CrossRef] [PubMed]
  18. A. Zuluaga, U. Utzinger, A. Durkin, H. Fuchs, A. Gillenwater, R. Jacob, B. Kemp, J. Fan, and R. Richards- Kortum, �??Fluorescence excitation emission matrices of human tissue: a system for in vivo measurement and data analysis,�?? Appl. Spectrosc. 53, 302-311 (1998). [CrossRef]
  19. R. A. Zangaro, L. Silveira, R. Manoharan, G. Zonios, I. Itzkan, R. R. Dasari, J. Van Dam, and M. S. Feld, �??Rapid multiexcitation fluorescence spectroscopy system for in vivo tissue diagnosis,�?? Appl. Opt. 35, 5211- 5219 (1996). [CrossRef] [PubMed]
  20. A. Mayevsky, B. Chance, �??Intracellular oxidation-reduction state measured in situ by a multichannel fiberoptic surface fluorometer,�?? Science 217, 537-40 (1982). [CrossRef] [PubMed]
  21. L. Burke, M. Modell, J. Niloff, M. Kobelin, G. Abu-Jawdeh, and A. Zelenchuk, �??Identification of squamous intraepithelial lesions: fluorescence of cervical tissue during colposcopy,�?? J. Lower Genital Tract Disease 3, 159-162 (1999). [CrossRef]
  22. G. A. Wagnieres, W. M. Star, and B. C. Wilson, �??In vivo fluorescence spectroscopy and imaging for oncological applications,�?? Photochem. Photobiol. 68, 603-32 (1998). [PubMed]
  23. D. G. Ferris, R. A. Lawhead, E. D. Dickman, N. Holtzapple, J. A. Miller, S. Grogan, S. Bambot, A. Agrawal, and M. L. Faupel, �??Multimodal hyperspectral imaging for the noninvasive diagnosis of cervical neoplasia,�?? J. of Lower Genital Tract Disease 5(2), 65-72 (2001).
  24. R. J. Nordstrom, L. Burke, J. M. Niloff, and J. F. Myrtle, �??Identification of cervical intraepithelial neoplasia (CIN) using UV-excited fluorescence and diffuse-reflectance tissue spectroscopy,�?? Lasers Surg. Med. 29, 118-127 (2001). [CrossRef] [PubMed]
  25. A. Bogaards, M.C.G. Aalders, C.C. Zeyl, S. de Blok, C. Dannecker, P. Hillemanns, H. Stepp, and H. J. C. M. Sterenborg, �??Localization and staging of cervical intraepithelial neoplasia using double ratio fluorescence imaging,�?? J. Biomed. Opt. 7(2), 215-220 (2002). [CrossRef] [PubMed]
  26. T. Wu, J. Y. Qu, T. H. Cheung, K. W. K. Lo, and and M. Y. Yu, �??Preliminary study of detecting neoplastic growths in vivo with real time calibrated autofluorescence imaging,�?? Opt. Express 11, 291-298 (2003), <a href="http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-4-291">http://www.opticsexpress.org/abstract.cfm?URI=OPEX-11-4-291</a> [CrossRef] [PubMed]
  27. V. Trujillo, D. Sandison, U. Utzinger, N. Ramanujam, M. Follen Mitchell, and R. Richards-Kortum, �??Method to determine tissue fluorescence efficiency in vivo and predict signal to noise ratio for spectrometers,�?? Appl. Spectrosc. 52, 943-951 (1998). [CrossRef]
  28. U. Utzinger, V. Trujillo, N. Atkinson, M. F. Mitchell, S. Cantor, and R. Richards-Kortum, �??Performance estimation of diagnostic tests for cervical precancer based on fluorescence spectroscopy: effects on tissue type, sample size population, and signal to noise ratio,�?? IEEE Trans. Biomed. Eng. 49, 1293-1303 (1999). [CrossRef]
  29. S. K. Chang, M. Follen, A. Malpica, U. Utzinger, S. Gtaerkel, D. Cox, N. Atkinson, C. MacAulay, and R. Richards-Kortum, �??Optimal excitation wavelengths for discrimination of cervical neoplasia,�?? IEEE Trans. Biomed. Eng. 49, 1102-1111 (2002). [CrossRef] [PubMed]
  30. N. Ramanujam, M. Follen Mitchell, A. Mahadevan, S. Thomsen, A. Malpica, T. Wright, N. Atkinson, and R. Richards-Kortum, �??,�?? Lasers Surg. Med. 19, 46-62 (1996). [CrossRef] [PubMed]
  31. R. J. Kurman and D. Solomon, The Bethesda System for Reporting Cervical/Vaginal Cytologic Diagnosis (Springer-Verlag, New York, 1994). [CrossRef]

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