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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 15 — Jul. 28, 2003
  • pp: 1817–1826

In vivo size and shape measurement of the human upper airway using endoscopic long-range optical coherence tomography

Julian J. Armstrong, Matthew S. Leigh, Ian D. Walton, Andrei V. Zvyagin, Sergey A. Alexandrov, Stefan Schwer, David D. Sampson, David R. Hillman, and Peter R. Eastwood  »View Author Affiliations

Optics Express, Vol. 11, Issue 15, pp. 1817-1826 (2003)

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We describe a long-range optical coherence tomography system for size and shape measurement of large hollow organs in the human body. The system employs a frequency-domain optical delay line of a configuration that enables the combination of high-speed operation with long scan range. We compare the achievable maximum delay of several delay line configurations, and identify the configurations with the greatest delay range. We demonstrate the use of one such long-range delay line in a catheter-based optical coherence tomography system and present profiles of the human upper airway and esophagus in vivo with a radial scan range of 26 millimeters. Such quantitative upper airway profiling should prove valuable in investigating the pathophysiology of airway collapse during sleep (obstructive sleep apnea).

© 2003 Optical Society of America

OCIS Codes
(170.2150) Medical optics and biotechnology : Endoscopic imaging
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

Original Manuscript: April 18, 2003
Revised Manuscript: July 25, 2003
Published: July 28, 2003

Julian Armstrong, Matthew Leigh, Ian Walton, Andrei Zvyagin, Sergey Alexandrov, Stefan Schwer, David Sampson, David Hillman, and Peter Eastwood, "In vivo size and shape measurement of the human upper airway using endoscopic longrange optical coherence tomography," Opt. Express 11, 1817-1826 (2003)

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