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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 23 — Nov. 17, 2003
  • pp: 3116–3121

Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography

R. A. Leitgeb, L. Schmetterer, W. Drexler, A. F. Fercher, R. J. Zawadzki, and T. Bajraszewski  »View Author Affiliations


Optics Express, Vol. 11, Issue 23, pp. 3116-3121 (2003)
http://dx.doi.org/10.1364/OE.11.003116


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Abstract

We interfaced color Doppler Fourier domain optical coherence tomography (CD-FDOCT) with a commercial OCT system to perform in vivo studies of human retinal blood flow in real time. FDOCT does not need reference arm scanning and records one full depth and Doppler profile in parallel. The system operates with an equivalent A-scan rate of 25 kHz and allows real time imaging of the color encoded Doppler information together with the tissue morphology at a rate of 2–4 tomograms (40×512 pixel) per second. The recording time of a single tomogram (160×512 data points) is only 6,4ms. Despite the high detection speed we achieve a system sensitivity of 86dB using a beam power of 500µW at the cornea. The fundus camera allows simultaneous view for selection of the region of interest. We observe bi-directional blood flow and pulsatility of blood velocity in retinal vessels with a Doppler detection bandwidth of 12.5 kHz and a longitudinal velocity sensitivity in tissue of 200µm/s.

© 2003 Optical Society of America

OCIS Codes
(170.3340) Medical optics and biotechnology : Laser Doppler velocimetry
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Research Papers

History
Original Manuscript: September 23, 2003
Revised Manuscript: November 5, 2003
Published: November 17, 2003

Citation
Rainer Leitgeb, L. Schmetterer, W. Drexler, A. Fercher, R. Zawadzki, and T. Bajraszewski, "Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography," Opt. Express 11, 3116-3121 (2003)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-11-23-3116


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References

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