OSA's Digital Library

Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 25 — Dec. 15, 2003
  • pp: 3445–3454

Time-resolved diffusive optical imaging using pseudo-random bit sequences

Nan Guang Chen and Quing Zhu  »View Author Affiliations


Optics Express, Vol. 11, Issue 25, pp. 3445-3454 (2003)
http://dx.doi.org/10.1364/OE.11.003445


View Full Text Article

Enhanced HTML    Acrobat PDF (413 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We have experimentally implemented a time-resolved diffusive optical tomography system via a novel spread spectrum approach. A low power (~5 mW) laser diode modulated with pseudo-random bit sequences replaces the short pulse laser used in conventional time-resolved optical systems, while the time-resolved transmittance is retrieved by correlating the detected signal with the stimulation sequence. Temporal point spread functions of diffusive light propagating through a turbid medium have been measured with remarkably low noise levels and a temporal resolution of 2.24 nanosecond. We also present results of 2-dimensional scanning imaging experiments as evidences of the great potential of this new imaging technique.

© 2003 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Research Papers

History
Original Manuscript: October 28, 2003
Revised Manuscript: December 8, 2003
Published: December 15, 2003

Citation
Nan Chen and Quing Zhu, "Time-resolved diffusive optical imaging using pseudo-random bit sequences," Opt. Express 11, 3445-3454 (2003)
http://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-11-25-3445


Sort:  Journal  |  Reset  

References

  1. B. Chance, �??Near-infrared (NIR) optical spectroscopy characterizes breast tissue hormonal and age status,�?? Academic Radiology 8, 209-210 (2001). [CrossRef] [PubMed]
  2. B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand and J. Butler, �??Non- Invasive in vivo characterization of breast tumors using photon migration spectroscopy,�?? Neoplasia 2, 26-40 (2000). [CrossRef] [PubMed]
  3. S. Fantini, M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. M. Mantulin, K. T. Moesta, P. M. Schlag, and M. Kashke, �??Frequency-domain optical mammography: Edge effect corrections,�?? Med. Phys. 23, 146-157 (1996). [CrossRef]
  4. T. L. Troy, D. L. Page, E. M. Sevick-Muraca, �??Optical properties of normal and diseased breast tissues: prognosis for optical mammography,�?? J. Biomed. Opt. 1, 342-355 (1996). [CrossRef] [PubMed]
  5. Q. Zhu, T. Durduran, M. Holboke, V. Ztziachristos, A. Yodh, �??An imager that combines near infrared diffusive light and ultrasound,�?? Optics letters 24, 1050-1052 (1999). [CrossRef]
  6. B. Chance, Z. Zhuang, C. UnAh, and L. Lipton, �??Cognition-activated low-frequency modulation of light absorption in human brain,�?? Proc. Natl. Acad. Sci. USA 90, 3770-3074 (1993). [CrossRef] [PubMed]
  7. D. A. Boas, T. Gaudette, G. Strangman, X. F. Cheng, J. J. A. Marota, J. B. Mandeville, �??The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics�?? Neuroimage 13, 76-90 (2001). [CrossRef] [PubMed]
  8. J. C. Hebden, A.Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, J. S. Wyatt, �??Three-dimensional optical tomography of the premature infant brain,�?? Phys. Med. Biol. 47, 4155-4166 (2002). [CrossRef] [PubMed]
  9. C. J. Aldrich, D. Dantona, J. A. D. Spencer, J. S. Wyatt, D. M. Peebles, D. T. Delpy, E. O. R. Reynolds, �??The Effect of Maternal pushing in fetal cerebral oxygenation and blood-volume during the 2nd stage of labor,�?? Brit. J. Obstet. Gynaec. 102, 448-453 (1995). [CrossRef] [PubMed]
  10. J. Beuthan, U. Netz, O. Minet, A. D. Klose, A. H. Hielscher, A. Scheel, J. Henniger, G. Muller, �??Light scattering study of rheumatoid arthritis,�?? Quantum Electronics 32, 945-952 (2002). [CrossRef]
  11. H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, J. F. Dunn, �??Near-infrared imaging in the small animal brain: optimization of fiber positions,�?? J. Biomed. Opt. 8, 102-110 (2003). [CrossRef] [PubMed]
  12. Q. Zhu, M. Huang, N. G. Chen, K. Zarfos, B. Jagjivan, M. Kane, S. H. Kurtzman, �??Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases,�?? Neoplasia 5, 379-389 (2003). [PubMed]
  13. K. A. Kang, D. F. Bruley, J. M. Londono, B. Chance, �??Localization of a fluorescent object in highly scattering media via frequency response analysis of near infrared-time resolved spectroscopy spectra,�?? Ann. Biomed. Engr. 26, 138-145 (1998). [CrossRef]
  14. J. C. Hebden, H. Veenstra, H. Dehghani, E. M. C. Hillman, M. Schweiger, S. R. Arridge, D. T. Delpy, �??Three-dimensional time-resolved optical tomography of a conical breast phantom,�?? Appl. Opt. 40, 3278-3287 (2001). [CrossRef]
  15. D. Grosenick, H. Wabnitz, H. Rinneberg, �??Time-resolved imaging of solid phantoms for optical mammography,�?? Appl. Opt. 36, 221-231 (1997). [CrossRef] [PubMed]
  16. W. Cai, S. K. Gayen, M. Xu, M. Zevallos, M. Alrubaiee, M. Lax, R. R. Alfano, �??Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements,�?? Appl. Opt. 38, 4237-4246 (1999). [CrossRef]
  17. F. Gao, H. J. Zhao, Y. Yamada, �??Improvement of image quality in diffuse optical tomography by use of full time-resolved data,�?? Appl. Opt. 41, 778-791 (2002). [CrossRef] [PubMed]
  18. S. Behin-Ain, T. van Doorn, J. R. Patterson, �??Spatial resolution in fast time-resolved transillumination imaging: an indeterministic Monte Carlo approach,�?? Phys. Med. Biol. 47 2935-2945 (2002). [CrossRef] [PubMed]
  19. N. G. Chen, Q. Zhu, �??Optical Tomography with Early Arriving Photons: Sensitivity and Resolution Analysis,�?? Proc. SPIE 4250, 37-44 (2001). [CrossRef]
  20. G. W. Faris, M. Banks, �??Upconverting time gate for imaging through highly scattering media,�?? Opt. Lett. 19, 1813-1815 (1994). [CrossRef] [PubMed]
  21. R. Mahon, M. D. Duncan, L. L. Tankersley, J. Reintjes, �??Time-gated imaging through dense scatterers with a Raman amplifier,�?? Appl. Opt. 32, 7425-7433 (1993). [CrossRef] [PubMed]
  22. L. Wang, P. P. Ho, C. Liu, G. Zhang, A. A. Alfano, �??Ballistic 2-D imaging through scattering wall using an ultrafast Kerr gate,�?? Science 253, 769-771 (1991). [CrossRef] [PubMed]
  23. F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, D. T. Delpy, �??A 32-channel time-resolved instrument for medical optical tomography,�?? Rev. Sci. Instrum. 71, 256-265 (2000). [CrossRef]
  24. H. Eda, Oda I, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, M. Tamura, �??Multichannel time-resolved optical tomographic imaging system,�?? Rev. Sci. Instrum. 70, 3595-3602 (1999). [CrossRef]
  25. N. G. Chen, Q. Zhu, �??Time-resolved optical measurements with spread spectrum excitation,�?? Opt. Lett. 27, 1806-1808 (2002). [CrossRef]
  26. D. A. Boas, M. A. O�??Leary, B. Chance, and A. G. Yodh, �??Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal to noise analysis,�?? Appl. Opt. 36, 75-92 (1997). [CrossRef] [PubMed]
  27. Y. Chen, X. Intes, S. Zhou, C. Mu, M. Holboke, A. G. Yodh, B. Chance, �??Detection sensitivity and optimization of phased array system,�?? Proc. SPIE 4250, 211-218 (2001). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited