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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 25 — Dec. 15, 2003
  • pp: 3445–3454

Time-resolved diffusive optical imaging using pseudo-random bit sequences

Nan Guang Chen and Quing Zhu  »View Author Affiliations

Optics Express, Vol. 11, Issue 25, pp. 3445-3454 (2003)

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We have experimentally implemented a time-resolved diffusive optical tomography system via a novel spread spectrum approach. A low power (~5 mW) laser diode modulated with pseudo-random bit sequences replaces the short pulse laser used in conventional time-resolved optical systems, while the time-resolved transmittance is retrieved by correlating the detected signal with the stimulation sequence. Temporal point spread functions of diffusive light propagating through a turbid medium have been measured with remarkably low noise levels and a temporal resolution of 2.24 nanosecond. We also present results of 2-dimensional scanning imaging experiments as evidences of the great potential of this new imaging technique.

© 2003 Optical Society of America

OCIS Codes
(170.3890) Medical optics and biotechnology : Medical optics instrumentation
(170.5280) Medical optics and biotechnology : Photon migration
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Research Papers

Original Manuscript: October 28, 2003
Revised Manuscript: December 8, 2003
Published: December 15, 2003

Nan Chen and Quing Zhu, "Time-resolved diffusive optical imaging using pseudo-random bit sequences," Opt. Express 11, 3445-3454 (2003)

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  1. B. Chance, �??Near-infrared (NIR) optical spectroscopy characterizes breast tissue hormonal and age status,�?? Academic Radiology 8, 209-210 (2001). [CrossRef] [PubMed]
  2. B. Tromberg, N. Shah, R. Lanning, A. Cerussi, J. Espinoza, T. Pham, L. Svaasand and J. Butler, �??Non- Invasive in vivo characterization of breast tumors using photon migration spectroscopy,�?? Neoplasia 2, 26-40 (2000). [CrossRef] [PubMed]
  3. S. Fantini, M. A. Franceschini, G. Gaida, E. Gratton, H. Jess, W. M. Mantulin, K. T. Moesta, P. M. Schlag, and M. Kashke, �??Frequency-domain optical mammography: Edge effect corrections,�?? Med. Phys. 23, 146-157 (1996). [CrossRef]
  4. T. L. Troy, D. L. Page, E. M. Sevick-Muraca, �??Optical properties of normal and diseased breast tissues: prognosis for optical mammography,�?? J. Biomed. Opt. 1, 342-355 (1996). [CrossRef] [PubMed]
  5. Q. Zhu, T. Durduran, M. Holboke, V. Ztziachristos, A. Yodh, �??An imager that combines near infrared diffusive light and ultrasound,�?? Optics letters 24, 1050-1052 (1999). [CrossRef]
  6. B. Chance, Z. Zhuang, C. UnAh, and L. Lipton, �??Cognition-activated low-frequency modulation of light absorption in human brain,�?? Proc. Natl. Acad. Sci. USA 90, 3770-3074 (1993). [CrossRef] [PubMed]
  7. D. A. Boas, T. Gaudette, G. Strangman, X. F. Cheng, J. J. A. Marota, J. B. Mandeville, �??The accuracy of near infrared spectroscopy and imaging during focal changes in cerebral hemodynamics�?? Neuroimage 13, 76-90 (2001). [CrossRef] [PubMed]
  8. J. C. Hebden, A.Gibson, R. M. Yusof, N. Everdell, E. M. C. Hillman, D. T. Delpy, S. R. Arridge, T. Austin, J. H. Meek, J. S. Wyatt, �??Three-dimensional optical tomography of the premature infant brain,�?? Phys. Med. Biol. 47, 4155-4166 (2002). [CrossRef] [PubMed]
  9. C. J. Aldrich, D. Dantona, J. A. D. Spencer, J. S. Wyatt, D. M. Peebles, D. T. Delpy, E. O. R. Reynolds, �??The Effect of Maternal pushing in fetal cerebral oxygenation and blood-volume during the 2nd stage of labor,�?? Brit. J. Obstet. Gynaec. 102, 448-453 (1995). [CrossRef] [PubMed]
  10. J. Beuthan, U. Netz, O. Minet, A. D. Klose, A. H. Hielscher, A. Scheel, J. Henniger, G. Muller, �??Light scattering study of rheumatoid arthritis,�?? Quantum Electronics 32, 945-952 (2002). [CrossRef]
  11. H. Xu, H. Dehghani, B. W. Pogue, R. Springett, K. D. Paulsen, J. F. Dunn, �??Near-infrared imaging in the small animal brain: optimization of fiber positions,�?? J. Biomed. Opt. 8, 102-110 (2003). [CrossRef] [PubMed]
  12. Q. Zhu, M. Huang, N. G. Chen, K. Zarfos, B. Jagjivan, M. Kane, S. H. Kurtzman, �??Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases,�?? Neoplasia 5, 379-389 (2003). [PubMed]
  13. K. A. Kang, D. F. Bruley, J. M. Londono, B. Chance, �??Localization of a fluorescent object in highly scattering media via frequency response analysis of near infrared-time resolved spectroscopy spectra,�?? Ann. Biomed. Engr. 26, 138-145 (1998). [CrossRef]
  14. J. C. Hebden, H. Veenstra, H. Dehghani, E. M. C. Hillman, M. Schweiger, S. R. Arridge, D. T. Delpy, �??Three-dimensional time-resolved optical tomography of a conical breast phantom,�?? Appl. Opt. 40, 3278-3287 (2001). [CrossRef]
  15. D. Grosenick, H. Wabnitz, H. Rinneberg, �??Time-resolved imaging of solid phantoms for optical mammography,�?? Appl. Opt. 36, 221-231 (1997). [CrossRef] [PubMed]
  16. W. Cai, S. K. Gayen, M. Xu, M. Zevallos, M. Alrubaiee, M. Lax, R. R. Alfano, �??Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements,�?? Appl. Opt. 38, 4237-4246 (1999). [CrossRef]
  17. F. Gao, H. J. Zhao, Y. Yamada, �??Improvement of image quality in diffuse optical tomography by use of full time-resolved data,�?? Appl. Opt. 41, 778-791 (2002). [CrossRef] [PubMed]
  18. S. Behin-Ain, T. van Doorn, J. R. Patterson, �??Spatial resolution in fast time-resolved transillumination imaging: an indeterministic Monte Carlo approach,�?? Phys. Med. Biol. 47 2935-2945 (2002). [CrossRef] [PubMed]
  19. N. G. Chen, Q. Zhu, �??Optical Tomography with Early Arriving Photons: Sensitivity and Resolution Analysis,�?? Proc. SPIE 4250, 37-44 (2001). [CrossRef]
  20. G. W. Faris, M. Banks, �??Upconverting time gate for imaging through highly scattering media,�?? Opt. Lett. 19, 1813-1815 (1994). [CrossRef] [PubMed]
  21. R. Mahon, M. D. Duncan, L. L. Tankersley, J. Reintjes, �??Time-gated imaging through dense scatterers with a Raman amplifier,�?? Appl. Opt. 32, 7425-7433 (1993). [CrossRef] [PubMed]
  22. L. Wang, P. P. Ho, C. Liu, G. Zhang, A. A. Alfano, �??Ballistic 2-D imaging through scattering wall using an ultrafast Kerr gate,�?? Science 253, 769-771 (1991). [CrossRef] [PubMed]
  23. F. E. W. Schmidt, M. E. Fry, E. M. C. Hillman, J. C. Hebden, D. T. Delpy, �??A 32-channel time-resolved instrument for medical optical tomography,�?? Rev. Sci. Instrum. 71, 256-265 (2000). [CrossRef]
  24. H. Eda, Oda I, Y. Ito, Y. Wada, Y. Oikawa, Y. Tsunazawa, M. Takada, Y. Tsuchiya, Y. Yamashita, M. Oda, A. Sassaroli, Y. Yamada, M. Tamura, �??Multichannel time-resolved optical tomographic imaging system,�?? Rev. Sci. Instrum. 70, 3595-3602 (1999). [CrossRef]
  25. N. G. Chen, Q. Zhu, �??Time-resolved optical measurements with spread spectrum excitation,�?? Opt. Lett. 27, 1806-1808 (2002). [CrossRef]
  26. D. A. Boas, M. A. O�??Leary, B. Chance, and A. G. Yodh, �??Detection and characterization of optical inhomogeneities with diffuse photon density waves: a signal to noise analysis,�?? Appl. Opt. 36, 75-92 (1997). [CrossRef] [PubMed]
  27. Y. Chen, X. Intes, S. Zhou, C. Mu, M. Holboke, A. G. Yodh, B. Chance, �??Detection sensitivity and optimization of phased array system,�?? Proc. SPIE 4250, 211-218 (2001). [CrossRef]

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