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Optics Express

Optics Express

  • Editor: Michael Duncan
  • Vol. 11, Iss. 25 — Dec. 15, 2003
  • pp: 3503–3517

Refractive index tomography of turbid media by bifocal optical coherence refractometry

Andrei V. Zvyagin, K. K. M. B. Dilusha Silva, Sergey A. Alexandrov, Timothy R. Hillman, Julian J. Armstrong, Takuya Tsuzuki, and David D. Sampson  »View Author Affiliations

Optics Express, Vol. 11, Issue 25, pp. 3503-3517 (2003)

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We demonstrate tomographic imaging of the refractive index of turbid media using bifocal optical coherence refractometry (BOCR). The technique, which is a variant of optical coherence tomography, is based on the measurement of the optical pathlength difference between two foci simultaneously present in a medium of interest. We describe a new method to axially shift the bifocal optical pathlength that avoids the need to physically relocate the objective lens or the sample during an axial scan, and present an experimental realization based on an adaptive liquid-crystal lens. We present experimental results, including video clips, which demonstrate refractive index tomography of a range of turbid liquid phantoms, as well as of human skin in vivo.

© 2003 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.5710) Instrumentation, measurement, and metrology : Refraction
(170.4580) Medical optics and biotechnology : Optical diagnostics for medicine
(170.7050) Medical optics and biotechnology : Turbid media
(180.1790) Microscopy : Confocal microscopy

ToC Category:
Research Papers

Original Manuscript: November 10, 2003
Revised Manuscript: December 3, 2003
Published: December 15, 2003

Andrei Zvyagin, K. K. M. B. Silva, Sergey Alexandrov, Timothy Hillman, Julian Armstrong, Takuya Tsuzuki, and David Sampson, "Refractive index tomography of turbid media by bifocal optical coherence refractometry," Opt. Express 11, 3503-3517 (2003)

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